This core will provide support for patient recruitment and assessment using clinical, neuropsychological, neurophysiological and neuroimaging-based approaches. It will consist of 3 subcores devoted respectively to recruitment, neurophysiology and neuroimaging. Dr. Pamela Butler will serve as overall Core Director, and will also direct the Neurophysiology subcore. As an expert in Clinical Psychology and Neurophysiology, and a """"""""user"""""""" of MRI, Dr. Butler is ideally suited to direct an integrated core. Further, Dr. Butler has active funded collaborations with members of the Sub-Cores as well as with other imaging and ERP investigators participating in this Conte application. Dr. Karen Nolan will serve as co-leader, and will direct the patient assessment subcore. Dr. Nolan is a licensed psychologist with expertise in neuropsychological testing and neurogenetics. Drs. Citrome and Maayan serve as directors of the Clinical Research and Evaluation Facility (CREF) and the Outpatient Research Service (ORS), respectively, and will collaborate on this project. Dr. Nadine Revheim is an expert in assessment, outcomes research and cognitive remediation and will oversee the clinical aspects of the core. Dr. Elisa Dias will oversee clinical recordings in humans. Dr. Gary Linn will oversee clinical recordings in monkeys. Dr. Helen Chao will oversee banking of DNA samples.
Specific aims of the core are 1) To provide core support in patient recruitment and clinical assessment to Center projects, 2) To provide core support in behavioral assessment, neurophysiology (steady-state and transient ERP) and neuroimaging (structural and functional MRI) to Center projects, and 3)To conduct core-related research in ERP and MRl-based assessment of sensory processing deficits in schizophrenia. The Core will serve three primary roles: first, it will enhance capabilities in patient recruitment and in clinical, neuro? physiological- and neuroimaging-based assessment at NKI/NYUSoM, to the benefit of Project 1 as well as other ongoing NlMH-funded schizophrenia projects. Second, it will provide neurophysiology and neuroimaging support to off-site projects (Projects 5,6) to permit them to incorporate advanced neurophysiological and neuroimaging approaches into their collaborative research projects, and permit MRI study of off-site patients at NYUSoM. Finally, it will port clinical ERP techniques to in collaboration with Project 2, to permit directly parallel human/primate neurophysiological approaches.

Public Health Relevance

Schizophrenia is a major mental disorder. Neurocognitive dysfunction is a core component of schizophrenia and a major determinant of poor long-term outcome. This Core is part of a Center application to determine brain mechanisms underlying neurocognitive dysfunction in schizophrenia with particular emphasis on sensory processing dysfunction. This Core will coordinate patient recruitment and assessment in order to evaluate deficits in sensory processing in patients with schizophrenia, in collaboration with other projects and core programs.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH086385-05
Application #
8502378
Study Section
Special Emphasis Panel (ZMH1-ERB-F)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2013
Total Cost
$339,194
Indirect Cost
$78,414
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Kantrowitz, Joshua T; Nolan, Karen A; Epstein, Michael L et al. (2017) Neurophysiological Effects of Bitopertin in Schizophrenia. J Clin Psychopharmacol 37:447-451
Lee, M; Sehatpour, P; Hoptman, M J et al. (2017) Neural mechanisms of mismatch negativity dysfunction in schizophrenia. Mol Psychiatry 22:1585-1593
Sershen, Henry; Hashim, Audrey; Dunlop, David S et al. (2016) Modulating NMDA Receptor Function with D-Amino Acid Oxidase Inhibitors: Understanding Functional Activity in PCP-Treated Mouse Model. Neurochem Res 41:398-408
Smiley, John F; Hackett, Troy A; Bleiwas, Cynthia et al. (2016) Reduced GABA neuron density in auditory cerebral cortex of subjects with major depressive disorder. J Chem Neuroanat 76:108-121
Kantrowitz, Joshua T; Epstein, Michael L; Beggel, Odeta et al. (2016) Neurophysiological mechanisms of cortical plasticity impairments in schizophrenia and modulation by the NMDA receptor agonist D-serine. Brain 139:3281-3295
Hillyard, Steven A; Störmer, Viola S; Feng, Wenfeng et al. (2016) Cross-modal orienting of visual attention. Neuropsychologia 83:170-178
van Atteveldt, Nienke; Musacchia, Gabriella; Zion-Golumbic, Elana et al. (2015) Complementary fMRI and EEG evidence for more efficient neural processing of rhythmic vs. unpredictably timed sounds. Front Psychol 6:1663
Javitt, Daniel C (2015) Current and emergent treatments for symptoms and neurocognitive impairment in schizophrenia. Curr Treat Options Psychiatry 1:107-120
Javitt, Daniel C (2015) Neurophysiological models for new treatment development in schizophrenia: early sensory approaches. Ann N Y Acad Sci 1344:92-104
Haegens, Saskia; Barczak, Annamaria; Musacchia, Gabriella et al. (2015) Laminar Profile and Physiology of the ? Rhythm in Primary Visual, Auditory, and Somatosensory Regions of Neocortex. J Neurosci 35:14341-52

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