The brain processes information and generates behavior by transmitting signals at its synapses, which connect neurons into vast networks of communicating cells. These networks, known as neural circuits, are not static but are modified throughout life by experience. Such neural circuit plasticity is critical for the brain to develop normally and perform all of its important functions, including learning and memory. When brain plasticity mechanisms function abnormally, however, devastating mental illnesses often ensue. Thus, a major goal of neuroscience research is to understand the detailed mechanisms by which the brain activity generated by experiences modifies neural circuit behavior. This occurs in large part because neural activity continually adjusts the efficiency or strength of synaptic communication between neurons, a process known as synaptic plasticity. Despite the importance of synaptic plasticity for brain development and higher brain functions, relatively little is known about its molecular mechanisms other than it is commonly triggered by activity-dependent changes in intracellular calcium levels. This Conte Center will bring together four leading investigators who will use an innovative molecular screening approach combined with sophisticated biochemical, electrophysiological, and imaging assays to elucidate novel intracellular signaling pathways that underlie different forms of synaptic plasticity and how these forms of synaptic plasticity modify circuit function. The new Insights into synaptic plasticity mechanisms generated by this Conte Center will influence a broad array of neuroscientists working on a wide range of topics related to normal and pathological brain function. The Conte Center will also provide the research community with novel genetic tools that can be used to manipulate intracellular signaling pathways throughout the brain as well as novel transgenic mouse models that can be used to explore the roles of different signaling pathways and forms of synaptic plasticity in normal and pathological behaviors. Thus the Conte Center will provide both technological and intellectual innovations to one of the most important areas of neuroscience research with far ranging implications for our understanding of normal and diseased brain function.
The effectiveness of communication between nerve cells is modified by experience and these modifications are crucial for all normal brain functions including learning and memory. The goal of this project is to determine the molecular mechanisms that are responsible for these modifications. Such information will lead to a better understanding of the causes of mental illness and eventually to the development of more efficacious treatments.
|Steinberg, Elizabeth E; Christoffel, Daniel J; Deisseroth, Karl et al. (2015) Illuminating circuitry relevant to psychiatric disorders with optogenetics. Curr Opin Neurobiol 30:16-Sep|
|Acuna, Claudio; Guo, Qingchen; Burré, Jacqueline et al. (2014) Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca²? sensitivity. Neuron 82:1088-100|
|Rothwell, Patrick E; Fuccillo, Marc V; Maxeiner, Stephan et al. (2014) Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors. Cell 158:198-212|
|Lammel, Stephan; Lim, Byung Kook; Malenka, Robert C (2014) Reward and aversion in a heterogeneous midbrain dopamine system. Neuropharmacology 76 Pt B:351-9|
|Xu, Junjie; Bacaj, Taulant; Zhou, Amy et al. (2014) Structure and Ca²?-binding properties of the tandem C? domains of E-Syt2. Structure 22:269-80|
|Soler-Llavina, Gilberto J; Arstikaitis, Pamela; Morishita, Wade et al. (2013) Leucine-rich repeat transmembrane proteins are essential for maintenance of long-term potentiation. Neuron 79:439-46|
|Xu, Wei; Sudhof, Thomas C (2013) A neural circuit for memory specificity and generalization. Science 339:1290-5|
|Foldy, Csaba; Malenka, Robert C; Sudhof, Thomas C (2013) Autism-associated neuroligin-3 mutations commonly disrupt tonic endocannabinoid signaling. Neuron 78:498-509|
|Zhou, Peng; Pang, Zhiping P; Yang, Xiaofei et al. (2013) Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion. EMBO J 32:159-71|
|Sarti, Federica; Zhang, Zhenjie; Schroeder, Jessica et al. (2013) Rapid suppression of inhibitory synaptic transmission by retinoic acid. J Neurosci 33:11440-50|
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