The Neurobiology and Genetics Laboratory Core (NGLC) will carry out specialized assays for multiple projects and thereby insure optimal and comparable reliability across projects. It offers an economy of scale and moves resources as study priorities change. The assays fall into several major domains. Toxicology assays such as ones using brain tissue provide a longer time frame on most recent exposure to psychotropic drugs than body fluids since brain levels tend to be 10-40 times higher. This will be valuable for the postmortem brain studies in Project 1 where drugs may alter the results. The second domain is genetics and epigenetics. Here assays will include gene variants, methylation and gene expression assays. The latter domain is applicable to Projects 1 and 2. The core will assay salivary Cortisol in Project 5 and the responses will also be correlated with findings from Projects 3 and 4. Since Project 6 is looking at how suicidal behavior may be predicted by the large imaging data sets from Projects 3 and 4, it will also consider the impact of the laboratory data from Project 5. Thus, findings from this core are relevant directly or indirectly to every project.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
1P50MH090964-01A1
Application #
8605251
Study Section
Special Emphasis Panel (ZMH1-ERB-L (02))
Project Start
2013-07-19
Project End
2018-06-30
Budget Start
2013-07-19
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$214,046
Indirect Cost
$80,100
Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
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Schnieder, Tatiana P; Trencevska, Iskra; Rosoklija, Gorazd et al. (2014) Microglia of prefrontal white matter in suicide. J Neuropathol Exp Neurol 73:880-90
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Moreno, Carmen; Hasin, Deborah S; Arango, Celso et al. (2013) The bipolar-depressive continuum in the National Epidemiologic Survey on Alcohol and Related Conditions. Bipolar Disord 15:112-3
Sher, Leo; Mann, J John; Oquendo, Maria A (2013) Sleep, psychiatric disorders and suicide. J Psychiatr Res 47:135