Project 6 involves developing statistical methodology that will be applicable to many of the very high dimensional datasets that are being gathered as part of the Conte Center. In particular, we will focus on models with single outcome variables and very high-dimensional predictors, e.g., using gene expression data to discriminate between suicide attempters and depressed non attempters, or using brain imaging data to predict a patient's response to treatment for depression. This methodology will employ powerful newly developing statistical concepts and tools including functional data analytic methods, machine learning techniques, and prescreening algorithms. Emphasis will be on developing models that can both achieve accurate predictions and provide stable interpretable models, allowing for a deeper understanding of the biological basis of suicidal behavior and mental illness. The project involves development of appropriate methodology, application both to existing datasets and to those that will be gathered as part of the Conte Center, and comparison among the various modeling strategies using both simulation studies and real data validations.

Public Health Relevance

In order to better understand the biological basis of suicidal behavior and mental illness, powerful methods for modeling data with very high dimensional data (e.g., brain imaging data, gene expression data) are required. This project is focused on developing appropriate statistical methodology that will allow for both accurate predictions and stable, interpretable models in situations arising as part of the Conte Center.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
1P50MH090964-01A1
Application #
8605258
Study Section
Special Emphasis Panel (ZMH1-ERB-L (02))
Project Start
2013-07-19
Project End
2018-06-30
Budget Start
2013-07-19
Budget End
2014-06-30
Support Year
1
Fiscal Year
2013
Total Cost
$162,995
Indirect Cost
$60,995
Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
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Moreno, Carmen; Hasin, Deborah S; Arango, Celso et al. (2013) The bipolar-depressive continuum in the National Epidemiologic Survey on Alcohol and Related Conditions. Bipolar Disord 15:112-3
Sher, Leo; Mann, J John; Oquendo, Maria A (2013) Sleep, psychiatric disorders and suicide. J Psychiatr Res 47:135