The purpose of the GENETICS CORE is to provide for genetic analysis of genomic DNA samples collected by the Research PROJECTS. Centralized genotyping of human and primate samples will maximize our efficiency by utilizing consistent methods for carrying out and interpreting genotyping data. This CORE will have four primary goals, which are to a) extract genomic DNA from peripheral blood or saliva from individual PROJECTS;b) to genotype the serotonin transporter promoter repeat polymorphism 5-HTTLRR in human and primate samples;c) to genotype single nucleotide polymorphisrns (SNPs) and a repeat polymorphism from five serotonin-related genes in human samples;and dj to genotype DNA variants showing genetic association in a replication sample of human samples. The CORE will work closely with the PROJECTS and with the biostatistics and imaging COREs to allow efficient sharing and analysis of genotypic data.

Public Health Relevance

Evidence suggests that the serotonergic system plays an important role in human brain development. We anticipate that our work will facilitate genetic aspects of this research that is being carried using a variety of experimental systems.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH090966-04
Application #
8478205
Study Section
Special Emphasis Panel (ZMH1-ERB-M)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
4
Fiscal Year
2013
Total Cost
$70,275
Indirect Cost
Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Spann, Marisa N; Serino, Dana; Bansal, Ravi et al. (2015) Morphological features of the neonatal brain following exposure to regional anesthesia during labor and delivery. Magn Reson Imaging 33:213-21
Horga, Guillermo; Kaur, Tejal; Peterson, Bradley S (2014) Annual research review: Current limitations and future directions in MRI studies of child- and adult-onset developmental psychopathologies. J Child Psychol Psychiatry 55:659-80
Polo-Kantola, Paivi; Lampi, Katja M; Hinkka-Yli-Salomaki, Susanna et al. (2014) Obstetric risk factors and autism spectrum disorders in Finland. J Pediatr 164:358-65
Goodman, Jarid; Marsh, Rachel; Peterson, Bradley S et al. (2014) Annual research review: The neurobehavioral development of multiple memory systems--implications for childhood and adolescent psychiatric disorders. J Child Psychol Psychiatry 55:582-610
Spann, Marisa N; Bansal, Ravi; Rosen, Tove S et al. (2014) Morphological features of the neonatal brain support development of subsequent cognitive, language, and motor abilities. Hum Brain Mapp 35:4459-74
Yan, Xu; Zhou, Minxiong; Ying, Lingfang et al. (2014) A fast schema for parameter estimation in diffusion kurtosis imaging. Comput Med Imaging Graph 38:469-80
Gyllenberg, David; Gissler, Mika; Malm, Heli et al. (2014) Specialized service use for psychiatric and neurodevelopmental disorders by age 14 in Finland. Psychiatr Serv 65:367-73
He, Xiaofu; Liu, Wei; Li, Xuzhou et al. (2014) Automated assessment of the quality of diffusion tensor imaging data using color cast of color-encoded fractional anisotropy images. Magn Reson Imaging 32:446-56
Yan, Xu; Zhou, Minxiong; Ying, Lingfang et al. (2013) Evaluation of optimized b-value sampling schemas for diffusion kurtosis imaging with an application to stroke patient data. Comput Med Imaging Graph 37:272-80
Talati, Ardesheer; Weissman, Myrna M; Hamilton, Steven P (2013) Using the high-risk family design to identify biomarkers for major depression. Philos Trans R Soc Lond B Biol Sci 368:20120129

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