The Biostatistics Core will assist the Center in its efforts to quantify the role of genetic and pharmacologic influences of seroteronergic modulation on the development of brain structure and functioning, and of behaviour. The Biostatistics Core will focus on providing resources for consultation and performing statistical analysis for all projects. Specifically, we will assist in meeting Center goals by: 1) assisting in the statistical design and power analysis of all center projects;2) performing statistical analyses on data from a large birth-cohort study to determine effects of maternal SRI exposure on development and neuropsychiatric outcomes in offspring;3) performing statistical analyses on brain imaging data as well as data on clinical endophenotypes of depression, to quantify 5htllpr genotype and other interacting genotype-specific changes in brain structure/function, as well as association of these genes with clinical endophenotypes and neurophysiologic measures in a high risk 3-generation cohort;4) performing statistical analysis to determine the effect of SSRI exposure and genetic factors on infant brain structure and neurophysiology and early life temperament;and 5) assisting in analyzing data generated from animal models to determine serotoninmediated genetic and pharmacologic influences on developing brain structure across species. In addition, investigators in the Biostatistics Core will work closely with those in the genetics and imaging cores to develop novel and sophisticated statistical methods to integrate phenotypic, genotypic, neurophysiologic, and imaging data. These activities will be accomplished by regular individual and group meetings with project and core directors, to review data and suggest statistical approaches. Students from T32 training grants, both graduate students and fellows, will also be involved in this work.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH090966-05
Application #
8661055
Study Section
Special Emphasis Panel (ZMH1)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
New York State Psychiatric Institute
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
12204
Talati, Ardesheer; Odgerel, Zagaa; Wickramaratne, Priya J et al. (2017) Associations between serotonin transporter and behavioral traits and diagnoses related to anxiety. Psychiatry Res 253:211-219
Hao, Xuejun; Talati, Ardesheer; Shankman, Stewart A et al. (2017) Stability of Cortical Thinning in Persons at Increased Familial Risk for Major Depressive Disorder Across 8 Years. Biol Psychiatry Cogn Neurosci Neuroimaging 2:619-625
Anderson, Micheline R; Miller, Lisa; Wickramaratne, Priya et al. (2017) Genetic Correlates of Spirituality/Religion and Depression: A Study in Offspring and Grandchildren at High and Low Familial Risk for Depression. Spiritual Clin Pract (Wash D C ) 4:43-63
Desai, Jay; Huo, Yuankai; Wang, Zhishun et al. (2017) Reduced perfusion in Broca's area in developmental stuttering. Hum Brain Mapp 38:1865-1874
Svob, Connie; Liu, Jie; Wickramaratne, Priya et al. (2017) Neuroanatomical correlates of familial risk-for-depression and religiosity/spirituality. Spiritual Clin Pract (Wash D C ) 4:32-42
Talati, Ardesheer; Wickramaratne, Priya J; Wesselhoeft, Rikke et al. (2017) Prenatal tobacco exposure, birthweight, and offspring psychopathology. Psychiatry Res 252:346-352
Weissman, Myrna M; Berry, Obianuju O; Warner, Virginia et al. (2016) A 30-Year Study of 3 Generations at High Risk and Low Risk for Depression. JAMA Psychiatry 73:970-7
Talati, Ardesheer; Odgerel, Zagaa; Wickramaratne, Priya J et al. (2016) Brain derived neurotrophic factor moderates associations between maternal smoking during pregnancy and offspring behavioral disorders. Psychiatry Res 245:387-391
Subaran, Ryan L; Odgerel, Zagaa; Swaminathan, Rajeswari et al. (2016) Novel variants in ZNF34 and other brain-expressed transcription factors are shared among early-onset MDD relatives. Am J Med Genet B Neuropsychiatr Genet 171B:333-41
Bansal, Ravi; Peterson, Bradley S; Gingrich, Jay et al. (2016) Serotonin signaling modulates the effects of familial risk for depression on cortical thickness. Psychiatry Res 248:83-93

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