This Conte Center resubmission will use a multi-modal, multi-species approach to investigate the neurobiological underpinnings of social decision-making. Three cores provide administrative, neuroimaging, and participant recruitment and assessment resources for four Projects that are each directed by internationally renowned leaders in social neuroscience and decision neuroscience, all of whom have a track record of scientific collaboration, student training, and expertise in the topic of the planned studies. The Projects constitute a cohesive set of experiments in humans and monkeys that will use the resources of the Caltech Brain Imaging Center for fMRI studies of the brain, existing collaborations with three hospitals for intracranial recordings in neurosurgical patients, together with the resources of labs at Caltech and at Cambridge for electrophysiological recordings in nonhuman primates. Project 1 provides a foundational investigation of basic social reward processing (e.g., representing the value of emotional faces), and how this compares with nonsocial reward processing (e.g., the value of juice). Project 2 investigates how we can learn choices by observing other people's decisions. Project 3 investigates how we can make decisions that are based on another person's value (such as in altruistic behaviors). Project 4 investigates the connectivity of the brain structures revealed by the other Projects to underlie social decision-making, such as the amygdala and parts of the prefrontal cortex. Each Project includes both fMRI and electrophysiology, and studies in both humans and monkeys. This science is woven into a training and outreach program emphasizing dissemination and diversity;and all data are made available for data sharing. The uniform recruitment and assessment of participants, the tight integration and communication between Projects, and the collaborative track record of the team will leverage these studies to a systematic and coordinated investigation of the largest outstanding questions in social decision-making, an enterprise that only a Conte Center mechanism could make possible.
This is a basic research application, whose relevance for mental health lies in providing fundamental neurobiological insights into the circuits that underlie social decision-making. Of particular value will be the dissection of specific components of this process, information that will be invaluable in targeted interventions in diseases with compromised social decision-making, ranging from autism to schizophrenia to mood disorders.
|Wang, Shuo; Tsuchiya, Naotsugu; New, Joshua et al. (2015) Preferential attention to animals and people is independent of the amygdala. Soc Cogn Affect Neurosci 10:371-80|
|Schaafsma, Sara M; Pfaff, Donald W; Spunt, Robert P et al. (2015) Deconstructing and reconstructing theory of mind. Trends Cogn Sci 19:65-72|
|Andersen, Richard A; Andersen, Kristen N; Hwang, Eun Jung et al. (2014) Optic ataxia: from Balint's syndrome to the parietal reach region. Neuron 81:967-83|
|Lak, Armin; Stauffer, William R; Schultz, Wolfram (2014) Dopamine prediction error responses integrate subjective value from different reward dimensions. Proc Natl Acad Sci U S A 111:2343-8|
|Spunt, Robert P; Adolphs, Ralph (2014) Validating the Why/How contrast for functional MRI studies of Theory of Mind. Neuroimage 99:301-11|
|Liljeholm, Mimi; Dunne, Simon; O'Doherty, John P (2014) Anterior insula activity reflects the effects of intentionality on the anticipation of aversive stimulation. J Neurosci 34:11339-48|
|Stetson, Chess; Andersen, Richard A (2014) The parietal reach region selectively anti-synchronizes with dorsal premotor cortex during planning. J Neurosci 34:11948-58|
|Paul, Lynn K; Corsello, Christina; Kennedy, Daniel P et al. (2014) Agenesis of the corpus callosum and autism: a comprehensive comparison. Brain 137:1813-29|
|Anderson, David J; Adolphs, Ralph (2014) A framework for studying emotions across species. Cell 157:187-200|
|Hare, Todd A; Hakimi, Shabnam; Rangel, Antonio (2014) Activity in dlPFC and its effective connectivity to vmPFC are associated with temporal discounting. Front Neurosci 8:50|
Showing the most recent 10 out of 16 publications