Building on the prior Projects, this last Project will take our investigations of the social decision-making system to the network level and investigate the influences among its components using techniques such as pharmacological inactivation, rare human lesion subjects, diffusion imaging, BOLD coherence and spike-field coherence. It will pave the way for major future efforts, beyond the scope of the present application, eventually to understand the complete functional architecture for social decision-making implemented by a spatially distributed neural system. Specifically, we will focus on how the components of the system identified in the other Projects (e.g., amygdala, dorsolateral and orbital prefrontal cortex) interact. This requires investigations of two kinds: (1) demonstration of the functional effects on one another (Aims 1-2), and (2) characterization of their connectivity (Aims 3-4). This Project features a very close integration of studies in humans and monkeys, uses a diverse set of approaches ranging from diffusion imaging to tracer studies to pharmacological inactivation and spike-field coherence, and leverages many of the data collected under the other Projects. There are four Specific Aims: (1) to characterize interactions between prefrontal and amygdala regions in monkeys and humans using spike-field coherence (collaboration with Dr Doris Tsao);(2) to investigate causal influences of the amygdala on the prefrontal cortex using reversible pharmacological inactivation in monkeys and study of rare human lesion subjects (collaboration with Dr. Richard Andersen);(3) to describe structural and functional connectivity networks in monkeys (4) to describe structural and functional connectivity networks in humans. This final Project thus extends the studies from the prior Projects to the network level, and brings together many of the PIs from the prior Projects.

Public Health Relevance

Many mental illnesses are thought to arise from abnormal connectivity between different brain regions, rather than merely pathology within a region. Autism, for instance, is now often thought of as a disconnection syndrome. This Project will provide important data towards understanding mental illnessess in which abnormal long-range connectivity plays a role in pathology.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Specialized Center (P50)
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Special Emphasis Panel (ZMH1-ERB-S (02))
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California Institute of Technology
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Pastor-Bernier, Alexandre; Plott, Charles R; Schultz, Wolfram (2017) Monkeys choose as if maximizing utility compatible with basic principles of revealed preference theory. Proc Natl Acad Sci U S A 114:E1766-E1775
Wang, Shuo; Adolphs, Ralph (2017) Reduced specificity in emotion judgment in people with autism spectrum disorder. Neuropsychologia 99:286-295
Zhang, Carey Y; Aflalo, Tyson; Revechkis, Boris et al. (2017) Partially Mixed Selectivity in Human Posterior Parietal Association Cortex. Neuron 95:697-708.e4
Spunt, Robert P; Ellsworth, Emily; Adolphs, Ralph (2017) The neural basis of understanding the expression of the emotions in man and animals. Soc Cogn Affect Neurosci 12:95-105
Collette, Sven; Pauli, Wolfgang M; Bossaerts, Peter et al. (2017) Neural computations underlying inverse reinforcement learning in the human brain. Elife 6:
Dubois, Julien; Oya, Hiroyuki; Tyszka, J Michael et al. (2017) Causal mapping of emotion networks in the human brain: Framework and initial findings. Neuropsychologia :
Diederen, Kelly M J; Ziauddeen, Hisham; Vestergaard, Martin D et al. (2017) Dopamine Modulates Adaptive Prediction Error Coding in the Human Midbrain and Striatum. J Neurosci 37:1708-1720
Reber, Justin; Feinstein, Justin S; O'Doherty, John P et al. (2017) Selective impairment of goal-directed decision-making following lesions to the human ventromedial prefrontal cortex. Brain 140:1743-1756
Spunt, Robert P; Adolphs, Ralph (2017) The neuroscience of understanding the emotions of others. Neurosci Lett :
Reed, Chrystal M; Birch, Kurtis G; Kami?ski, Jan et al. (2017) Automatic detection of periods of slow wave sleep based on intracranial depth electrode recordings. J Neurosci Methods 282:1-8

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