This project addresses the role of functional circuitry of how memories are formed using a non-human primate model. Despite the great deal of evidence that both the prefrontal cortex (PFC) and medial temporal lobe (MTL) are critical for normal memory, there has been remarkably little experimental effort toward understanding how these two systems interact This is, in part, because neurophysiological studies have largely focused on either the PFC or MTL individually. As a result, much of what we know about them is based on comparisons between different animals with different training histories, often on different tasks, and/or different levels of experience. This confounds their comparison and precludes examination of the precise timing of their activity that gives insight into network properties and signal flow. Our goal is a more integrated understanding of the PFC and MTL. We will accomplish this by recording simultaneously from multiple electrodes in multiple subregions of the PFC and MTL while monkeys form and recall new context guided associative memories and while they make inferences based on those memories. By comparing the relative neural latencies for memories to be formed and recalled, we will determine where memories are formed, how they are recalled, and how memory-related signals flow between the PFC and MTL.

Public Health Relevance

This work will bridge a critical and glaring gap in our understanding of memory: The establishment of homologies between the different subregions of the PFC and MTL of humans, monkeys, and rodents. These linkages will be key in validating animal models of memory disorders and thus provide new means for testing underlying cellular causes and assessing potential treatments.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH094263-04
Application #
8735993
Study Section
Special Emphasis Panel (ZMH1-ERB-S)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
4
Fiscal Year
2014
Total Cost
$196,929
Indirect Cost
$37,323
Name
Boston University
Department
Type
DUNS #
049435266
City
Boston
State
MA
Country
United States
Zip Code
02215
Rueckemann, Jon W; DiMauro, Audrey J; Rangel, Lara M et al. (2016) Transient optogenetic inactivation of the medial entorhinal cortex biases the active population of hippocampal neurons. Hippocampus 26:246-60
Ryals, Anthony J; Rogers, Lynn M; Gross, Evan Z et al. (2016) Associative Recognition Memory Awareness Improved by Theta-Burst Stimulation of Frontopolar Cortex. Cereb Cortex 26:1200-10
Place, Ryan; Farovik, Anja; Brockmann, Marco et al. (2016) Bidirectional prefrontal-hippocampal interactions support context-guided memory. Nat Neurosci 19:992-4
Keene, Christopher S; Bladon, John; McKenzie, Sam et al. (2016) Complementary Functional Organization of Neuronal Activity Patterns in the Perirhinal, Lateral Entorhinal, and Medial Entorhinal Cortices. J Neurosci 36:3660-75
Eichenbaum, Howard (2016) Still searching for the engram. Learn Behav 44:209-22
McKenzie, Sam; Keene, Christopher S; Farovik, Anja et al. (2016) Representation of memories in the cortical-hippocampal system: Results from the application of population similarity analyses. Neurobiol Learn Mem 134 Pt A:178-91
Chen, Zetao; Lowry, Stephanie; Jacobson, Adam et al. (2015) Bio-inspired homogeneous multi-scale place recognition. Neural Netw 72:48-61
Wang, Jane X; Voss, Joel L (2015) Long-lasting enhancements of memory and hippocampal-cortical functional connectivity following multiple-day targeted noninvasive stimulation. Hippocampus 25:877-83
Howard, Marc W; Eichenbaum, Howard (2015) Time and space in the hippocampus. Brain Res 1621:345-54
Puig, M Victoria; Miller, Earl K (2015) Neural Substrates of Dopamine D2 Receptor Modulated Executive Functions in the Monkey Prefrontal Cortex. Cereb Cortex 25:2980-7

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