The major objective of this core is to provide wet-lab technological support and expertise to the investigators in the Center. We anticipate that results from network reverse engineering modeling in Core 1 will make predictions about not only the role of individual genes but also the state of particular suites of genes and of networks. To identify the relationship between multiple phenotypes, stimuli, and genotypes, high-throughput biochemical, proteomic, and genetic screening is essential. Simultaneous molecular profiling of large numbers of gene products to assess genetic status, expression level or protein modification state can rapidly provide an overview of the state of a cellular system.

Public Health Relevance

This core will provide an experimental infrastructure for functional validation of computational predictions about associations between the detected genetic variation in patient DNA and onset of complex neuropsychiatric disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
3P50MH094267-04S1
Application #
8936052
Study Section
Special Emphasis Panel (ZMH1 (02))
Program Officer
Addington, Anjene M
Project Start
2011-09-22
Project End
2016-07-31
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
4
Fiscal Year
2014
Total Cost
$1
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
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