We wish to establish a Research Computing Core (RCC) to complement both the imaging core and to provide an underlying platform to support a seamless continuation of computation from the advanced technology and science provided from our partnering Pis, Drs. Hensch, Dulac and Lichtman. The Research Computing Core will pay special interest to the analysis and genomic/connectomic studies of imprinting within pan/albumin (PV)-positive GABAergic interneurons. Advanced tools for automated image segmentation of neurons, synapses, and genome wide informatics analysis will be developed in close collaboration within the imaging core led by Dr. Zhuang. These tools will also enhance and support the informatics analysis of genome studies from Dr. Dulac's team. In addition, significant information technology infrastructure will be provided to support multi-terabyte data sets resulting from Dr. Lichtman's laboratory studies.

Public Health Relevance

Through collaboration with Drs. Dulac, Lichtman, Hensch and our partner Dr Zhuang in the imaging core, the Research Computing Core (RCC) will help provide advanced computation, large scale genomic data analysis and support for our combined and continued studies into brain function shaped by the genetics and environment during critical periods of neuronal circuit development. This is a one of a kind endeavor pulling together existing partnerships into a cohesive core, further extending the ability for the Research Computing organization to not only support the individual faculty, but more importantly to actively extend the reach of the RCC to be able to reflect the true collaborative nature of a Conte Center. By also welcoming in students and researchers into the core RCC will be able to provide more than just traditional

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH094271-02
Application #
8381899
Study Section
Special Emphasis Panel (ZMH1-ERB-S)
Project Start
Project End
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
2
Fiscal Year
2012
Total Cost
$223,031
Indirect Cost
$91,060
Name
Harvard University
Department
Type
DUNS #
082359691
City
Cambridge
State
MA
Country
United States
Zip Code
02138
Cameron, Judy L; Eagleson, Kathie L; Fox, Nathan A et al. (2017) Social Origins of Developmental Risk for Mental and Physical Illness. J Neurosci 37:10783-10791
Lee, H H C; Bernard, C; Ye, Z et al. (2017) Genetic Otx2 mis-localization delays critical period plasticity across brain regions. Mol Psychiatry 22:680-688
Babcock, Hazen P; Zhuang, Xiaowei (2017) Analyzing Single Molecule Localization Microscopy Data Using Cubic Splines. Sci Rep 7:552
Morgan, Josh L; Lichtman, Jeff W (2017) Digital tissue and what it may reveal about the brain. BMC Biol 15:101
Morgan, Josh Lyskowski; Berger, Daniel Raimund; Wetzel, Arthur Willis et al. (2016) The Fuzzy Logic of Network Connectivity in Mouse Visual Thalamus. Cell 165:192-206
Mierau, Susanna B; Patrizi, Annarita; Hensch, Takao K et al. (2016) Cell-Specific Regulation of N-Methyl-D-Aspartate Receptor Maturation by Mecp2 in Cortical Circuits. Biol Psychiatry 79:746-54
Perez, Julio D; Rubinstein, Nimrod D; Dulac, Catherine (2016) New Perspectives on Genomic Imprinting, an Essential and Multifaceted Mode of Epigenetic Control in the Developing and Adult Brain. Annu Rev Neurosci 39:347-84
Morishita, Hirofumi; Cabungcal, Jan-Harry; Chen, Ying et al. (2015) Prolonged Period of Cortical Plasticity upon Redox Dysregulation in Fast-Spiking Interneurons. Biol Psychiatry 78:396-402
Richardson, Douglas S; Lichtman, Jeff W (2015) Clarifying Tissue Clearing. Cell 162:246-257
Kasthuri, Narayanan; Hayworth, Kenneth Jeffrey; Berger, Daniel Raimund et al. (2015) Saturated Reconstruction of a Volume of Neocortex. Cell 162:648-61

Showing the most recent 10 out of 27 publications