This Core provides expertise in biostatistics and database management across Projects that meet the needs of animal and human studies. The Core will offer resources for study design, statistical analysis, database management, data checking, entry, verification, transfer, and protocol management. This is a critical part of the Center and essential for high quality integrative research. Standard and specialized statistical and graphics software is available. Projects are linked by protocols for data transfer and statistical consultation is assimilated into design. Core B interacts with Core A to coordinate and track human and animal research participants, contributing to all Projects and to career development.
The expertise and services provided by this Core are essential for achieving high quality research in the Conte Center. The Core will ensure proper study design, smooth operations of the database, access to computing facilities, data security and data analysis. It will also provide education to trainees in experimental design and statistics.
|Tatard-Leitman, Valerie M; Jutzeler, Catherine R; Suh, Jimmy et al. (2015) Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability. Biol Psychiatry 77:556-68|
|Billingslea, Eddie N; Tatard-Leitman, Valerie M; Anguiano, Jaynie et al. (2014) Parvalbumin cell ablation of NMDA-R1 causes increased resting network excitability with associated social and self-care deficits. Neuropsychopharmacology 39:1603-13|
|Stujenske, Joseph M; Likhtik, Ekaterina; Topiwala, Mihir A et al. (2014) Fear and safety engage competing patterns of theta-gamma coupling in the basolateral amygdala. Neuron 83:919-33|
|Likhtik, Ekaterina; Gordon, Joshua A (2014) Circuits in sync: decoding theta communication in fear and safety. Neuropsychopharmacology 39:235-6|
|Kumar, Manoj; Duda, Jeffery T; Hwang, Wei-Ting et al. (2014) High resolution magnetic resonance imaging for characterization of the neuroligin-3 knock-in mouse model associated with autism spectrum disorder. PLoS One 9:e109872|
|Likhtik, Ekaterina; Stujenske, Joseph M; Topiwala, Mihir A et al. (2014) Prefrontal entrainment of amygdala activity signals safety in learned fear and innate anxiety. Nat Neurosci 17:106-13|
|Duman, Ronald S (2014) Pathophysiology of depression and innovative treatments: remodeling glutamatergic synaptic connections. Dialogues Clin Neurosci 16:11-27|