The oxytocin (OT) system is arguably the most viable target for pharmacologically enhancing social cognition in psychiatric disorders with compromised social cognition, including autism spectrum disorder (ASD). Central OT enhances key aspects of social behavior in animals, and intranasal (IN) OT modulates social cognition in humans. The mechanisms by which OT affects social cognition are not understood. We will launch a coordinated, interdisciplinary research program involving an outstanding team of investigators to test the hypothesis that OT enhances social cognition by increasing the salience and reinforcing value of social stimuli by modulating activity and functional connectivity of the amygdala and brain regions involved in reward. Project scientists will use cutting edge techniques to assess functional connectivity between brain regions during social interactions, responses of individual neurons in the amygdala to social stimuli, or social cognition in animals and humans. Projects 1 and 2 will use in vivo electrophysiology to examine the impact of OT on the neural representation of social stimuli in rodents and rhesus macaques. Project 3 will use cognitive tests to examine the impact of OT on social perception and social attunement in the primate. Project 4 will use cognitive testing and fMRI to examine the impact of OT on social cognition and neural activity in healthy and autistic humans. A Neurochemistry Core will provide vital services for the research projects and develop new tools for characterizing OT receptor expression in the brain. An Administrative Core will coordinate all Center related activities (seminar series, organizing meetings), will provide statistical consultation and coordinate outreach and training activities of Center personnel by strengthening existing relationships and forging new relationships with numerous organizations in the Atlanta area. As a result, the Center will create vibrant collaborative research, training and outreach environment that will have a national impact on mental health research. The data collected by Center faculty will have important translational implications that will directly impact novel strategies for pharmacologically treating social deficits in psychiatric disorders.

Public Health Relevance

Autism spectrum disorder (ASD) is characterized by core deficits in social cognition. Oxytocin as a key modulator of social information processing, and intranasal oxytocin has been proposed as a therapeutic for ASD. This Center team will use a multidisciplinary approach to investigate the neural mechanisms by which oxytocin enhances social information processing and social cognition, to inform future drug development.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH100023-02
Application #
8690157
Study Section
Special Emphasis Panel (ZMH1)
Program Officer
Simmons, Janine M
Project Start
2013-07-01
Project End
2018-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
2
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Emory University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Numan, Michael; Young, Larry J (2016) Neural mechanisms of mother-infant bonding and pair bonding: Similarities, differences, and broader implications. Horm Behav 77:98-112
Andari, Elissar (2016) The Need for a Theoretical Framework of Social Functioning to Optimize Targeted Therapies in Psychiatric Disorders. Biol Psychiatry 79:e5-7
Burkett, J P; Andari, E; Johnson, Z V et al. (2016) Oxytocin-dependent consolation behavior in rodents. Science 351:375-8
Ballesta, Sébastien; Mosher, Clayton P; Szep, Jeno et al. (2016) Social determinants of eyeblinks in adult male macaques. Sci Rep 6:38686
Arai, Aki; Hirota, Yu; Miyase, Naoki et al. (2016) A single prolonged stress paradigm produces enduring impairments in social bonding in monogamous prairie voles. Behav Brain Res 315:83-93
Shamay-Tsoory, Simone; Young, Larry J (2016) Understanding the Oxytocin System and Its Relevance to Psychiatry. Biol Psychiatry 79:150-2
Johnson, Zachary V; Walum, Hasse; Jamal, Yaseen A et al. (2016) Central oxytocin receptors mediate mating-induced partner preferences and enhance correlated activation across forebrain nuclei in male prairie voles. Horm Behav 79:8-17
Putnam, P T; Roman, J M; Zimmerman, P E et al. (2016) Oxytocin enhances gaze-following responses to videos of natural social behavior in adult male rhesus monkeys. Psychoneuroendocrinology 72:47-53
King, Lanikea B; Walum, Hasse; Inoue, Kiyoshi et al. (2016) Variation in the Oxytocin Receptor Gene Predicts Brain Region-Specific Expression and Social Attachment. Biol Psychiatry 80:160-9
Mosher, Clayton P; Zimmerman, Prisca E; Fuglevand, Andrew J et al. (2016) Tactile Stimulation of the Face and the Production of Facial Expressions Activate Neurons in the Primate Amygdala. eNeuro 3:

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