The objective of the Emory ACE Data Management &Analysis Core is to create an optimal scientific and technical environment for creating growth charts of social engagement from densely-sampled longitudinal data sets co-registered across multiple domains in order to explore mechanisms of risk and resilience in autism, a key aim of Projects l-V as well as the whole program project. To accomplish this goal, the Core will provide shared resources, facilities and expertise for data collection, processing, analysis, storage and retrieval to serve the entire program project, as well as acting as a common repository for sharing data between individual projects and transmitting results to NDAR.
The specific aims of the Core are: (1) Data Management: to meet the uniquely challenging data processing, management, storage and transmission needs of the entire program project;(2) Data Analysis: to provide a common methodological framework and shared computational infrastructure for carrying out state-of-the-art developmental profiling and statistical analysis of experimental measures collected across Projects l-V;(3) Training and Reliability: to provide common training in all of the novel data analysis techniques employed across projects, and to ensure that those techniques are deployed consistently and reliably across projects, using appropriate procedures for data management;and (4) Quality Control: to ensure that all data arising from the program project are of uniformly and exceptionally high quality, suitable for publication, submission to NDAR, and immediate use by other scientists. Key personnel will provide expertise in mathematical analysis, biostatistics, software engineering, and data processing needed to achieve the specific aims of each project. Shared facilities and infrastructure will be made available to support the data management and analysis needs of each project, including a central supercomputing facility, local workstations, and a suite of software tools customized for the data processing required in each project. Data management will be centralized on a common data server using RexDB, a custom-designed database commissioned from Prometheus Research specifically to handle large-volume clinical, behavioral, and experimental data sets, and their transmission to NDAR.

Public Health Relevance

This research will generate a unique collection of large-scale data sets based on clinical, behavioral, and experimental measures that map out the developmental unfolding of autism over the first years of life. The Emory ACE Data Management &Analysis Core will ensure that the full potential for sharing our data, extracting new information about autism, and rapidly translating that information into practice is realized, addressing the Interagency Autism Committee objectives for Early Detection, Data Sharing and Resources.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH100029-02
Application #
8539850
Study Section
Special Emphasis Panel (ZHD1-DSR-Y)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
2
Fiscal Year
2013
Total Cost
$40,386
Indirect Cost
$30,059
Name
Emory University
Department
Type
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
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Li, Longchuan; Hu, Xiaoping; Preuss, Todd M et al. (2013) Mapping putative hubs in human, chimpanzee and rhesus macaque connectomes via diffusion tractography. Neuroimage 80:462-74