The Emory ACE joins 8 laboratories in 3 institutions, creating a center for clinical and translational science built-from its outset--on the expectation of transformative impact on the community. Laboratories from the Marcus Autism Center, Emory University School of Medicine, and Yerkes National Primate Research Center combine methodological and conceptual expertise in child development, behavioral neuroscience, speech science, molecular genetics, and treatment research;all against the backdrop of a city-wide initiative for autism research driven by the largest pediatric healthcare system in the country, Children's Healthcare of Atlanta. The thematic mission of the Emory ACE guides each of its 5 projects and 4 cores: to unravel the developmental complexities of risk and resilience in autism spectrum disorders, so that we may advance the most effective and successful treatments for children. Projects I and II quantify the developmental unfolding of social visual (PI) and social vocal (Pll) engagement, from birth until 24 months of age, to identify profiles for positive outcome as well as risk factors for disability. Project III advances rigorous, randomized-control trials for treatmnt of ASD into infancy and toddlerhood, testing the extent to which developmental trajectories of social engagement (Projects I and II) predict treatment response and outcome. Also starting in infancy. Projects IV and V establish-for normative social development (PV) and a genetic means to its disruption (PIV)-a nonhuman primate model for interrogating the underpinnings of social disability in genes, brain, and behavior. Together, these Projects advance our understanding of the developmental unfolding of autism, and set the stage for changing the course of ASD prior to the point when disability is even fully manifest. Four Cores provide the resources to support these goals, spanning Assessment, Informatics, Administration and Training. In its efforts to meet and exceed the aspirational goals for autism set forth by the NIH Interagency Autism Coordinating Committee (lACC), the Emory ACE creates in its wake a new scientific community, focused on the translational social neuroscience of autism spectrum disorders, in the service of children and families.
The Emory ACE directly addresses the goals of the lACC by (1) examining how ASD affects development;(2) studying neurobiological and genetic causes of social disability;(3) developing new tools for objective, performance-based screening for ASD;(4) measuring risk and resilience factors to guide treatment and intervention;(5) developing interventions that target core ASD characteristics;and (6) promoting community access to innovative services.
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|Klin, Ami; Shultz, Sarah; Jones, Warren (2015) Social visual engagement in infants and toddlers with autism: early developmental transitions and a model of pathogenesis. Neurosci Biobehav Rev 50:189-203|
|Klin, Ami; Wetherby, Amy M; Woods, Juliann et al. (2015) Toward innovative, cost-effective, and systemic solutions to improve outcomes and well-being of military families affected by autism spectrum disorder. Yale J Biol Med 88:73-9|
|Cherel, Marie; Budin, Francois; Prastawa, Marcel et al. (2015) Automatic Tissue Segmentation of Neonate Brain MR Images with Subject-specific Atlases. Proc SPIE Int Soc Opt Eng 9413:|
|Klin, Ami; Klaiman, Cheryl; Jones, Warren (2015) Reducing age of autism diagnosis: developmental social neuroscience meets public health challenge. Rev Neurol 60 Suppl 1:S3-11|
|Oguz, Ipek; Styner, Martin; Sanchez, Mar et al. (2015) LOGISMOS-B for Primates: Primate Cortical Surface Reconstruction and Thickness Measurement. Proc SPIE Int Soc Opt Eng 9413:|
|Chawarska, Katarzyna; Shic, Frederick; Macari, Suzanne et al. (2014) 18-month predictors of later outcomes in younger siblings of children with autism spectrum disorder: a baby siblings research consortium study. J Am Acad Child Adolesc Psychiatry 53:1317-1327.e1|
|Gao, Hao; Li, Longchuan; Zhang, Kai et al. (2014) PCLR: phase-constrained low-rank model for compressive diffusion-weighted MRI. Magn Reson Med 72:1330-41|
|Lyu, Ilwoo; Kim, Sun Hyung; Seong, Joon-Kyung et al. (2013) Group-wise cortical correspondence via sulcal curve-constrained entropy minimization. Inf Process Med Imaging 23:364-75|
|Li, Longchuan; Hu, Xiaoping; Preuss, Todd M et al. (2013) Mapping putative hubs in human, chimpanzee and rhesus macaque connectomes via diffusion tractography. Neuroimage 80:462-74|
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