Previous research suggested that earlier intervention may contribute to better outcomes in autism. Answering the question """"""""how early?"""""""" has significant health and educational implications for age of screening and age of entry into early intervention for children with autism spectrum disorders (ASD). With the increased number of young children identified with ASD, there is a pressing need for evidence-based, manualized cost-efficient treatments that are accessible to and feasibly implemented by parents within their natural environments in community-based settings. Significant disparities in diagnosis and treatment of ASD have been found in racial and ethnic minority populations increasing the need for families from diverse cultural and socioeconomic backgrounds. The major objective of Project 3 is to directly compare two parent intervention conditions of the Early Social Interaction Project for 9 months on developmental trajectories of infants showing early risk for ASD. The control treatment is an information, education and support group (IES) offered weekly;the experimental treatment is a parent-implemented intervention (Pll) offered in 2 weekly individualized sessions to teach parents how to embed strategies to support social communication skills within everyday routines, activities, and places, in combination with IES. Project 3 will recruit 92 parent-infant dyads at 12 months of age from the high risk siblings being studied in the Emory ACE Center. High risk infants will screen positive on 2 of 3 screening measures indicating the presence of diagnostic features of ASD by 12 months of age. Families will be randomly assigned to either IES or lES+PII for 9 months.
The specific aims of this investigation are:
Aim 1) Effectiveness of Treatment- to compare the effectiveness of IES plus Pll on developmental trajectories of social communication, autism symptoms, social visual engagement, developmental skills, and adaptive behavior, compared to IES alone;
Aim 2) Mediators of Treatment- to determine whether growth trajectories of child active engagement and parent transactional support are mediators of response to intervention;
and Aim 3) Moderators of Treatment: - to identify individual child and family characteristics which predict response to intervention.

Public Health Relevance

This impact of this study will: 1) document improved outcomes for very young children with ASD receiving a manualized, community-based, cost efficient, appropriate, and effective intervention;and 2) substantiate that individualized intervention beginning by 12 months of age leads to better outcomes, providing evidence that early detection of autism is crucial to enable access to early intervention.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
5P50MH100029-03
Application #
8708986
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Emory University
Department
Type
DUNS #
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Na, Sabrina; Li, Longchuan; Crosson, Bruce et al. (2018) White matter network topology relates to cognitive flexibility and cumulative neurological risk in adult survivors of pediatric brain tumors. Neuroimage Clin 20:485-497
Murphy, Melissa M; Lindsey Burrell, T; Cubells, Joseph F et al. (2018) Study protocol for The Emory 3q29 Project: evaluation of neurodevelopmental, psychiatric, and medical symptoms in 3q29 deletion syndrome. BMC Psychiatry 18:183
Xu, Ting; Falchier, Arnaud; Sullivan, Elinor L et al. (2018) Delineating the Macroscale Areal Organization of the Macaque Cortex In Vivo. Cell Rep 23:429-441
Sifre, Robin; Olson, Lindsay; Gillespie, Scott et al. (2018) A Longitudinal Investigation of Preferential Attention to Biological Motion in 2- to 24-Month-Old Infants. Sci Rep 8:2527
Bradshaw, Jessica; Klaiman, Cheryl; Gillespie, Scott et al. (2018) Walking Ability is Associated with Social Communication Skills in Infants at High Risk for Autism Spectrum Disorder. Infancy 23:674-691
Zhang, Tuo; Kong, Jun; Jing, Ke et al. (2018) Optimization of macaque brain DMRI connectome by neuron tracing and myelin stain data. Comput Med Imaging Graph 69:9-20
Okuda, Paola Matiko Martins; Klaiman, Cheryl; Bradshaw, Jessica et al. (2017) Assessing Risk of Bias in Randomized Controlled Trials for Autism Spectrum Disorder. Front Psychiatry 8:265
Constantino, John N; Kennon-McGill, Stefanie; Weichselbaum, Claire et al. (2017) Infant viewing of social scenes is under genetic control and is atypical in autism. Nature 547:340-344
Oguz, Ipek; Styner, Martin; Sanchez, Mar et al. (2015) LOGISMOS-B for Primates: Primate Cortical Surface Reconstruction and Thickness Measurement. Proc SPIE Int Soc Opt Eng 9413:
Klin, Ami; Klaiman, Cheryl; Jones, Warren (2015) Reducing age of autism diagnosis: developmental social neuroscience meets public health challenge. Rev Neurol 60 Suppl 1:S3-11

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