Project 3 incorporates two distinct studies, each of which capitalizes on extensive longitudinal, affective behavioral phenotyping during infancy or early childhood to study early adult outcomes based on neuroimaging (Study 1) or induced pluripotent stem cells. Study 1's monozygotic (MZ) twin difference design allows us to distinguish whether observed differences in later brain structure and function are associated with environmental influences versus familial influences on early anxious temperament. The comparison of MZ cotwins, with their age-matched, grossly similar brain morphology, allows detection of more subtle MRI effects in humans than any competing non-experimental design. Study 2 is a pilot study that is coordinated with the nonhuman primate stem cell work in Project 1. We examine whether young adults who are slow in amygdala recovery to negative affect elicitation and chronically anxious differ from those selected to be rapid in amygdala recovery and non-anxious differ in gene expression and cellular electrophysiology of GABAergic neurons that are derived from induced pluripotent stem cells.

Public Health Relevance

Understanding the early origins as well as the brain bases for conditions such as anxiety and depression is an important priority for public health. These issues can be addressed in studies that carefully assess behavior and brain structure and function beginning in infancy and extending through adolescence. Employing identical twins in this research allows control of genetic differences that affect development.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-ERB-L (02))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Wisconsin Madison
United States
Zip Code
Shackman, A J; Fox, A S; Oler, J A et al. (2017) Heightened extended amygdala metabolism following threat characterizes the early phenotypic risk to develop anxiety-related psychopathology. Mol Psychiatry 22:724-732
Oler, Jonathan A; Tromp, Do P M; Fox, Andrew S et al. (2017) Connectivity between the central nucleus of the amygdala and the bed nucleus of the stria terminalis in the non-human primate: neuronal tract tracing and developmental neuroimaging studies. Brain Struct Funct 222:21-39
Sarkisian, Katherine; Van Hulle, Carol; Lemery-Chalfant, Kathryn et al. (2017) Childhood inhibitory control and adolescent impulsivity and novelty seeking as differential predictors of relational and overt aggression. J Res Pers 67:144-150
Kalin, Ned H (2017) Mechanisms underlying the early risk to develop anxiety and depression: A translational approach. Eur Neuropsychopharmacol 27:543-553
Bogdan, Ryan; Salmeron, Betty Jo; Carey, Caitlin E et al. (2017) Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential. Biol Psychiatry 82:165-175
Dean 3rd, D C; Planalp, E M; Wooten, W et al. (2017) Mapping White Matter Microstructure in the One Month Human Brain. Sci Rep 7:9759
Chung, Moo K; Hanson, Jamie L; Adluru, Nagesh et al. (2017) Integrative Structural Brain Network Analysis in Diffusion Tensor Imaging. Brain Connect 7:331-346
Miller, Michele M; Goldsmith, H Hill (2017) Profiles of Social-Emotional Readiness for 4-Year-Old Kindergarten. Front Psychol 8:132
Planalp, Elizabeth M; Van Hulle, Carol; Gagne, Jeffrey R et al. (2017) The Infant Version of the Laboratory Temperament Assessment Battery (Lab-TAB): Measurement Properties and Implications for Concepts of Temperament. Front Psychol 8:846
Planalp, Elizabeth M; Van Hulle, Carol; Lemery-Chalfant, Kathryn et al. (2017) Genetic and environmental contributions to the development of positive affect in infancy. Emotion 17:412-420

Showing the most recent 10 out of 74 publications