The scientific, training and dissemination efforts of the investigators in the proposed Silvio O. Conte Center for Translational Mental Health Research will be supported by a simple organizational structure that minimizes the constraints of traditional departmental or disciplinary barriers while maximizing the opportunities for collaborative interactions. With this in mind, the organizational framework forthe proposed Center is based primarily on the leadership of faculty from two departments at the University of Pittsburgh (the Department of Psychiatry in the School of Medicine and the Department of Neuroscience in the School of Arts and Sciences) and the Center for the Neural Basis of Cognition that spans the University of Pittsburgh and Carnegie Mellon University. Two major administrative/scientific committees, a Steering Committee and a Scientific Coordinating Committee, will support the Center Director in managing the activities of the Center. In addition, the members of an External Scientific Advisory Board will provide consultation and critiques of Center activities. In concert, these committees will ensure that the goals of the Center are achieved in accordance with the milestones described in the Center Plan. Scientific and administrative leadership of the Center will be provided by the Center Director, David A. Lewis, MD. Dr. Lewis will have responsibility for the overall scientific and fiscal management of the Center, for facilitating the interactions of basic and clinical research investigators engaged in collaborative projects, and for promoting the training and outreach efforts of the Center. The latter include specialized activities for an Undergraduate Summer Research Experience, a Pilot and Feasibility Program for eariy career stage investigators, mulitple events and a website dedicated to the dissemination of Center findings and related areas of knowledge, and the sharing of resources. Dr. Lewis will be assisted in these activities by an experienced administrative team.

Public Health Relevance

The Administrative Core, Steering Committee, Scientific Coordinating Committee, External Advisory Board and an experienced administrative team will support the scientific, training and dissemination efforts of the investigators in the proposed Silvio O. Conte Center for Translational Mental Health Research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Specialized Center (P50)
Project #
1P50MH103204-01
Application #
8816229
Study Section
Special Emphasis Panel (ZMH1-ERB-L (01))
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
$252,110
Indirect Cost
$68,455
Name
University of Pittsburgh
Department
Type
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Pafundo, Diego E; Miyamae, Takeaki; Lewis, David A et al. (2018) Presynaptic Effects of N-Methyl-D-Aspartate Receptors Enhance Parvalbumin Cell-Mediated Inhibition of Pyramidal Cells in Mouse Prefrontal Cortex. Biol Psychiatry 84:460-470
Hoftman, Gil D; Dienel, Samuel J; Bazmi, Holly H et al. (2018) Altered Gradients of Glutamate and Gamma-Aminobutyric Acid Transcripts in the Cortical Visuospatial Working Memory Network in Schizophrenia. Biol Psychiatry 83:670-679
Asafu-Adjei, Josephine K; Sampson, Allan R (2018) Covariate adjusted classification trees. Biostatistics 19:42-53
Chung, Daniel W; Chung, Youjin; Bazmi, H Holly et al. (2018) Altered ErbB4 splicing and cortical parvalbumin interneuron dysfunction in schizophrenia and mood disorders. Neuropsychopharmacology 43:2478-2486
Enwright Iii, J F; Huo, Z; Arion, D et al. (2018) Transcriptome alterations of prefrontal cortical parvalbumin neurons in schizophrenia. Mol Psychiatry 23:1606-1613
Huang, Ge; Ramachandran, Suchitra; Lee, Tai Sing et al. (2018) Neural Correlate of Visual Familiarity in Macaque Area V2. J Neurosci 38:8967-8975
Coffman, Brian A; Haigh, Sarah M; Murphy, Timothy K et al. (2018) Reduced auditory segmentation potentials in first-episode schizophrenia. Schizophr Res 195:421-427
Leathers, Marvin L; Olson, Carl R (2017) In monkeys making value-based decisions, amygdala neurons are sensitive to cue value as distinct from cue salience. J Neurophysiol 117:1499-1511
Arion, Dominique; Huo, Zhiguang; Enwright, John F et al. (2017) Transcriptome Alterations in Prefrontal Pyramidal Cells Distinguish Schizophrenia From Bipolar and Major Depressive Disorders. Biol Psychiatry 82:594-600
Hoftman, Gil D; Datta, Dibyadeep; Lewis, David A (2017) Layer 3 Excitatory and Inhibitory Circuitry in the Prefrontal Cortex: Developmental Trajectories and Alterations in Schizophrenia. Biol Psychiatry 81:862-873

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