In tasks requiring attention and working memory, prefrontal and parietal cortex exhibit functional connectivity in the form of oscillatory phase-locking. Project 4 will test the general hypothesis that phase-locking depends on direct connections between the two areas originating from neurons in layer 3. By monitoring electrical activity simultaneously at fine intervals from the cortical surface to the white matter, while monkeys engage in working memory (Aim 1) and attenfion (Aim 2), the experiments will test the speciflc predicfion that signs of funcfional connectivity are maximal in layer 3. By monitoring the electrical activity of identified projection neurons and by examining the impact of blocking projections between the two areas, the experiments will test the specific prediction that direct projections are critical for functional connectivity (Aim 3). Results obtained in Project 4 will have direct relevance to the Central Hypothesis regarding the origin of cognitive deflcits in schizophrenia. This hypothesis states that cognifive deficits arise because pathological changes in layer 3 pyramidal cells interfere with functional connectivity between prefrontal and parietal cortex. Projects 1-3 will focus on the properties of layer 3 pyramidal cells in the healthy brain and in schizophrenia. Project 5 will focus on funcfional connectivity in the healthy brain and in schizophrenia as measured with coherence and causality analyses. The unique contribufion of Project 4 will be to link these domains of inquiry by establishing the role of layer 3 neurons in functional connectivity as assessed with coherence and causality analyses.
This project will establish the role of layer 3 neurons in the cognitive deflcits in schizophrenia.
|Asafu-Adjei, Josephine K; Sampson, Allan R (2018) Covariate adjusted classification trees. Biostatistics 19:42-53|
|Chung, Daniel W; Chung, Youjin; Bazmi, H Holly et al. (2018) Altered ErbB4 splicing and cortical parvalbumin interneuron dysfunction in schizophrenia and mood disorders. Neuropsychopharmacology 43:2478-2486|
|Enwright Iii, J F; Huo, Z; Arion, D et al. (2018) Transcriptome alterations of prefrontal cortical parvalbumin neurons in schizophrenia. Mol Psychiatry 23:1606-1613|
|Huang, Ge; Ramachandran, Suchitra; Lee, Tai Sing et al. (2018) Neural Correlate of Visual Familiarity in Macaque Area V2. J Neurosci 38:8967-8975|
|Coffman, Brian A; Haigh, Sarah M; Murphy, Timothy K et al. (2018) Reduced auditory segmentation potentials in first-episode schizophrenia. Schizophr Res 195:421-427|
|Pafundo, Diego E; Miyamae, Takeaki; Lewis, David A et al. (2018) Presynaptic Effects of N-Methyl-D-Aspartate Receptors Enhance Parvalbumin Cell-Mediated Inhibition of Pyramidal Cells in Mouse Prefrontal Cortex. Biol Psychiatry 84:460-470|
|Hoftman, Gil D; Dienel, Samuel J; Bazmi, Holly H et al. (2018) Altered Gradients of Glutamate and Gamma-Aminobutyric Acid Transcripts in the Cortical Visuospatial Working Memory Network in Schizophrenia. Biol Psychiatry 83:670-679|
|Dorph-Petersen, Karl-Anton; Lewis, David A (2017) Postmortem structural studies of the thalamus in schizophrenia. Schizophr Res 180:28-35|
|Glausier, Jill R; Lewis, David A (2017) GABA and schizophrenia: Where we stand and where we need to go. Schizophr Res 181:2-3|
|Rocco, Brad R; DeDionisio, Adam M; Lewis, David A et al. (2017) Alterations in a Unique Class of Cortical Chandelier Cell Axon Cartridges in Schizophrenia. Biol Psychiatry 82:40-48|
Showing the most recent 10 out of 36 publications