Public Health Relevance

This research will examine the prevalence and incidence of narcolepsy within the Kaiser Permanente Northern California population. It will also assess how selected environmental and past health factors may be associated with the risk of developing narcolepsy. The multi-disciplinary team will work with the other projects to help understand what causes narcolepsy and provide direction to ways in which it may be treated.

Agency
National Institute of Health (NIH)
Type
Specialized Center (P50)
Project #
5P50NS023724-27
Application #
8705035
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
Budget End
Support Year
27
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Stanford University
Department
Type
DUNS #
City
Stanford
State
CA
Country
United States
Zip Code
94304
Mignot, Emmanuel J M (2014) History of narcolepsy at Stanford University. Immunol Res 58:315-39
Warby, Simon C; Wendt, Sabrina L; Welinder, Peter et al. (2014) Sleep-spindle detection: crowdsourcing and evaluating performance of experts, non-experts and automated methods. Nat Methods 11:385-92
Moore 4th, Hyatt; Winkelmann, Juliane; Lin, Ling et al. (2014) Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD. Sleep 37:1535-42
Goldbart, Aviv; Peppard, Paul; Finn, Laurel et al. (2014) Narcolepsy and predictors of positive MSLTs in the Wisconsin Sleep Cohort. Sleep 37:1043-51
Han, Fang; Lin, Ling; Schormair, Barbara et al. (2014) HLA DQB1*06:02 negative narcolepsy with hypocretin/orexin deficiency. Sleep 37:1601-8
Mahlios, Josh; De la Herran-Arita, Alberto K; Mignot, Emmanuel (2013) The autoimmune basis of narcolepsy. Curr Opin Neurobiol 23:767-73
Faraco, Juliette; Lin, Ling; Kornum, Birgitte Rahbek et al. (2013) ImmunoChip study implicates antigen presentation to T cells in narcolepsy. PLoS Genet 9:e1003270
Weiner Lachmi, Karin; Lin, Ling; Kornum, Birgitte Rahbek et al. (2012) DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status. Hum Immunol 73:405-10
Zeitzer, Jamie M; Kodama, Tohru; Buckmaster, Christine L et al. (2012) Time-course of cerebrospinal fluid histamine in the wake-consolidated squirrel monkey. J Sleep Res 21:189-94
Han, Fang; Lin, Ling; Li, Jing et al. (2012) TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy. Sleep Med 13:269-72

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