Core C: The Transgenic and Neurobehavior Core has three major aims:
Specific Aim #1 : To generate and maintain breeding colonies of transgenic and gene-targeted mouse lines and to provide cohorts of transgenic and gene-targeted mice for studies proposed in Projects #1 to #3 of the Center grant.
Specific Aim #2 : To establish C57BL/6 cogenic lines of the transgenic and gene-targeted mice used throughout the study.
Specific Aim #3 : To establish methods to examine behavioral motor and clinical deficits in mouse models of Parkinson's disease. Core C: The Transgenic and neurobehavior core will be a shared central resource of the Parkinson's Disease Research Center servicing Projects 1, 2, and 3 and will play a central role in our investigations in the pathogenesis of Parkinson's disease.

Public Health Relevance

Through the development and maintenance of new and existing mouse models of PD and the neurobehavioral analysis of these PD models, this core will provide the basis for transgenic technology and phenotypic analysis of mice as a central resource to all three projects in the Center to support their research into the pathogenesis of PD.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS038377-15
Application #
8533023
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
15
Fiscal Year
2013
Total Cost
$149,879
Indirect Cost
$58,489
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
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Tsika, Elpida; Glauser, Liliane; Moser, Roger et al. (2014) Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Hum Mol Genet 23:4621-38
Pirooznia, Sheila K; Dawson, Valina L; Dawson, Ted M (2014) Motor neuron death in ALS: programmed by astrocytes? Neuron 81:961-3
Lasagna-Reeves, Cristian A; Sengupta, Urmi; Castillo-Carranza, Diana et al. (2014) The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes. Acta Neuropathol Commun 2:56

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