The Core for this P50 contains four functional interactive units: 1) P50 Tissue Acquisition &Characterization (P50-TAC);2) Database &Biostatistics;3) MRI Imaging;and 4) Administration. These units were developed to support the activities of the research group during the previous round of support, and are being extended in their current form. The P50-TAC Unit is responsible for prospectively Identifying brain and spinal cord donors, conducting postmortem MRI imaging per protocol, expeditiously processing brain and spinal cord tissue postmortem, and performing standardized histological assessment of lesions for the specific purposes of Projects 1, 2 and 3. The Database &Biostatistics Unit will collaborate with the investigators to optimize study design, ensure statistical power, analyze data requiring statistical expertise, and to design, implement, and manage study databases. The MRI Imaging Unit will coordinate MRI imaging procedures;assure that each protocol results in acceptable Image quality;verify quality of primary MRI data;and assist with analysis of the data for Projects 3 and 4. The Administrative Unit will manage the budget, organize investigator and advisory committee meetings and assist with preparation of reports.
The Core is critical for the success of the P50 projects. The Tissue Acquisition and Characterization unit is a unique program that enables brain and spinal cord tissue donation. The tissues and images that are made available through this program are highly valuable for MS research. The projects also depend heavily on expert biostatistical support, as well as the database, MRI, and administrative support provided by the Core.
|Trapp, Bruce D; Vignos, Megan; Dudman, Jessica et al. (2018) Cortical neuronal densities and cerebral white matter demyelination in multiple sclerosis: a retrospective study. Lancet Neurol 17:870-884|
|Lowe, Mark J; Sakaie, Ken E; Beall, Erik B et al. (2016) Modern Methods for Interrogating the Human Connectome. J Int Neuropsychol Soc 22:105-19|
|Paz Soldán, M Mateo; Novotna, Martina; Abou Zeid, Nuhad et al. (2015) Relapses and disability accumulation in progressive multiple sclerosis. Neurology 84:81-8|
|Takeshita, Yukio; Obermeier, Birgit; Cotleur, Anne et al. (2014) An in vitro blood-brain barrier model combining shear stress and endothelial cell/astrocyte co-culture. J Neurosci Methods 232:165-72|
|Criste, Gerson; Trapp, Bruce; Dutta, Ranjan (2014) Axonal loss in multiple sclerosis: causes and mechanisms. Handb Clin Neurol 122:101-13|
|Dutta, Ranjan; Trapp, Bruce D (2014) Relapsing and progressive forms of multiple sclerosis: insights from pathology. Curr Opin Neurol 27:271-8|
|Beall, Erik B; Lowe, Mark J (2014) SimPACE: generating simulated motion corrupted BOLD data with synthetic-navigated acquisition for the development and evaluation of SLOMOCO: a new, highly effective slicewise motion correction. Neuroimage 101:21-34|
|Tutuncu, Melih; Tang, Junger; Zeid, Nuhad Abou et al. (2013) Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis. Mult Scler 19:188-98|
|Rudick, Richard A; Fisher, Elizabeth (2013) Preventing brain atrophy should be the gold standard of effective therapy in MS (after the first year of treatment): Yes. Mult Scler 19:1003-4|
|Dutta, Ranjan; Chomyk, Anthony M; Chang, Ansi et al. (2013) Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors. Ann Neurol 73:637-45|
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