The Core for this P50 contains four functional interactive units: 1) P50 Tissue Acquisition &Characterization (P50-TAC);2) Database &Biostatistics;3) MRI Imaging;and 4) Administration. These units were developed to support the activities of the research group during the previous round of support, and are being extended in their current form. The P50-TAC Unit is responsible for prospectively Identifying brain and spinal cord donors, conducting postmortem MRI imaging per protocol, expeditiously processing brain and spinal cord tissue postmortem, and performing standardized histological assessment of lesions for the specific purposes of Projects 1, 2 and 3. The Database &Biostatistics Unit will collaborate with the investigators to optimize study design, ensure statistical power, analyze data requiring statistical expertise, and to design, implement, and manage study databases. The MRI Imaging Unit will coordinate MRI imaging procedures;assure that each protocol results in acceptable Image quality;verify quality of primary MRI data;and assist with analysis of the data for Projects 3 and 4. The Administrative Unit will manage the budget, organize investigator and advisory committee meetings and assist with preparation of reports.

Public Health Relevance

The Core is critical for the success of the P50 projects. The Tissue Acquisition and Characterization unit is a unique program that enables brain and spinal cord tissue donation. The tissues and images that are made available through this program are highly valuable for MS research. The projects also depend heavily on expert biostatistical support, as well as the database, MRI, and administrative support provided by the Core.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS038667-15
Application #
8605568
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
15
Fiscal Year
2014
Total Cost
$261,381
Indirect Cost
$94,896
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195
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