The long-term overall goal of this Specialized Program of Translational Research in Acute Stroke SPOTRIAS) is to enhance and accelerate recovery of acute stroke patients by focused and innovative rapid nterventions for ischemic and hemorrhagic stroke. This will be achieved through the SPOTRIAS network as well as additional centers connected to the SPOTRIAS via the proposed projects. The Primary Specific Aims of this SPOTRIAS include three collaborative clinical studies, one translational pre-clinical study, and further development of four shared SPOTRIAS cores and the SPOTRIAS training program. Projects 1-3 are led by the UC SPOTRIAS Center. 1) Project 1: The Combination approach to Lysis utilizing Eptifibatide And rt-PA - Enhanced Regimen) or CLEARER Trial is a collaborative, multi-center, double-blind, randomized Phase II reperfusion trial of 100 subjects that tests the combination of 0.6 mg/kg of rt-PA and eptifibatide (a GP-llb/llla platelet receptor antagonist) administered within 3 hours of onset of ischemic stroke as compared to standard IV t-PA. 2) Project 2: The Spot Sign for Predicting and Treating Intracerebral Hemorrhage (ICH) Growth Study or STOP-IT Study is a collaborative multi-center phase-ll study of 184 subjects that examines the ability of contrast extravasation on CT angiography (CTA) to predict hematoma growth in patients with intracerebral hemorrhage and to explore the role CTA may play in treatment allocation using recombinant activated factor VII. 3) Project 3: Preclinical Models of Transcranial Ultrasound Thrombolysis (TRUST Study). TRUST will determine the optimal parameters for transcranial ultrasound thrombolysis in an in-vitro human clot model, and verify the safety of these optimized parameters as a therapy in an in-vivo rat ischemic stroke model. 4) Project 4: MR Rescue (NINDS/UCLA Lead Center). 5) Further development of four shared cores/databases for the SPOTRIAS network: a clinical patient database, a blood/tissue core, an imaging core, and a biostatistical/data management core. This includes the development of new projects that utilize these cores - such as a TIA proteomic study under development (UCSD Lead Center). 6) Continuation and further strengthening of the SPOTRIAS Training Program.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center (P50)
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Application #
Study Section
Special Emphasis Panel (ZNS1-SRB-G (21))
Program Officer
Janis, Scott
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University of Cincinnati
Schools of Medicine
United States
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Lees, Kennedy R; Selim, Magdy H; Molina, Carlos A et al. (2016) Early Versus Late Assessment of Stroke Outcome. Stroke 47:1416-9
Kandadai, Madhuvanthi A; Mukherjee, Prithviraj; Shekhar, Himanshu et al. (2016) Microfluidic manufacture of rt-PA -loaded echogenic liposomes. Biomed Microdevices 18:48
Chaisinanunkul, Napasri; Adeoye, Opeolu; Lewis, Roger J et al. (2015) Adopting a Patient-Centered Approach to Primary Outcome Analysis of Acute Stroke Trials Using a Utility-Weighted Modified Rankin Scale. Stroke 46:2238-43
Kandadai, Madhuvanthi A; Meunier, Jason M; Hart, Kimberley et al. (2015) Plasmin-loaded echogenic liposomes for ultrasound-mediated thrombolysis. Transl Stroke Res 6:78-87
Adeoye, Opeolu; Sucharew, Heidi; Khoury, Jane et al. (2015) Recombinant tissue-type plasminogen activator plus eptifibatide versus recombinant tissue-type plasminogen activator alone in acute ischemic stroke: propensity score-matched post hoc analysis. Stroke 46:461-4
Adeoye, Opeolu; Sucharew, Heidi; Khoury, Jane et al. (2015) Combined Approach to Lysis Utilizing Eptifibatide and Recombinant Tissue-Type Plasminogen Activator in Acute Ischemic Stroke-Full Dose Regimen Stroke Trial. Stroke 46:2529-33
Brandler, Ethan S; Sharma, Mohit; Sinert, Richard H et al. (2014) Prehospital stroke scales in urban environments: a systematic review. Neurology 82:2241-9
De Los Rios, Felipe; Kleindorfer, Dawn O; Guzik, Amy et al. (2014) Intravenous fibrinolysis eligibility: a survey of stroke clinicians' practice patterns and review of the literature. J Stroke Cerebrovasc Dis 23:2130-8
Zahuranec, Darin B; Lisabeth, Lynda D; Sánchez, Brisa N et al. (2014) Intracerebral hemorrhage mortality is not changing despite declining incidence. Neurology 82:2180-6
Stamova, Boryana; Jickling, Glen C; Ander, Bradley P et al. (2014) Gene expression in peripheral immune cells following cardioembolic stroke is sexually dimorphic. PLoS One 9:e102550

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