The major aim of this Core is to coordinate program budget, activities and communication between program participants and to coordinate training. In particular, the Core will coordinate: 1) program budget/subcontract arrangements, 2) biannual meetings in Chicago of P.I.s, key program personnel and external advisors, 3) archiving and distribution of program publications, 4) compilation and submission of annual NIH program renewal applications, 5) data management and compliance with NIH policies, 6) maintenance of a program web page and 7) training of graduate and postdoctoral students. The overall administration and direction of the program project will be the responsibility of the Program Director D. James Surmeier. Routine day- to-day administration of the program, including budgetary matters, correspondence and meetings will be the responsibility of David Kesner. He is a Manager of Research Administration for the Basic Science Administration of the Feinberg School of Medicine and has over 19 years of relevant experience in grants management. The Program Director and Project Principal Investigators will make budgetary and scientific decisions pertaining to individual projects jointly. These decisions will be made four times a year during videoconferences linking the two performance sites. In addition to business matters, these meetings will offer investigators participating in each project an opportunity to discuss and evaluate experimental progress of each project. The meetings will focus on an individual project on a rotating basis but this will be kept flexible to allow new discoveries to be discussed. Existing technologies will allow these conferences to take place from networked workstations, providing an opportunity to share data in a variety of formats and stages of analysis. Three of the program participants (Surmeier, Chan and Miller) will have neighboring lab space, allowing for daily interactions. Dr. Bevan is in space located across the street, allowing easy interactions. Both Internal and External Advisory Committees will conduct program review. Our Internal Advisory Committee will be composed of experts in motor systems, cellular/molecular physiology, mitochondria, neuro- adaptations and Parkinson's disease. The members - Drs. Tanya Simuni, John Kessler, Lee Miller and Paul Schumacker - are drawn from the Feinberg School of Medicine. This committee will meet with the Center Director and team leaders twice a year to discuss the scientific progress of the Center as well as governance and administration issues. Two members of a four member External Advisory Committee will perform an annual review of the Udall Center. These consultants will spend two days evaluating program progress and providing advice. Each consultant will provide a written report after visiting. This report will be distributed and, if needed, remedial plans will be formulated, implemented and documented.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center (P50)
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Special Emphasis Panel (ZNS1-SRB-J (03))
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Northwestern University at Chicago
United States
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Wilson, Charles J; Barraza, David; Troyer, Todd et al. (2014) Predicting the responses of repetitively firing neurons to current noise. PLoS Comput Biol 10:e1003612
Surmeier, D James; Graves, Steven M; Shen, Weixing (2014) Dopaminergic modulation of striatal networks in health and Parkinson's disease. Curr Opin Neurobiol 29:109-17
Sanchez-Padilla, Javier; Guzman, Jaime N; Ilijic, Ema et al. (2014) Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase. Nat Neurosci 17:832-40
Gittis, Aryn H; Berke, Joshua D; Bevan, Mark D et al. (2014) New roles for the external globus pallidus in basal ganglia circuits and behavior. J Neurosci 34:15178-83
Deister, Christopher A; Dodla, Ramana; Barraza, David et al. (2013) Firing rate and pattern heterogeneity in the globus pallidus arise from a single neuronal population. J Neurophysiol 109:497-506
Atherton, Jeremy F; Menard, Ariane; Urbain, Nadia et al. (2013) Short-term depression of external globus pallidus-subthalamic nucleus synaptic transmission and implications for patterning subthalamic activity. J Neurosci 33:7130-44
Dodla, Ramana; Wilson, Charles J (2013) Effect of phase response curve skewness on synchronization of electrically coupled neuronal oscillators. Neural Comput 25:2545-610
Wilson, C J (2013) Active decorrelation in the basal ganglia. Neuroscience 250:467-82
Sulzer, David; Surmeier, D James (2013) Neuronal vulnerability, pathogenesis, and Parkinson's disease. Mov Disord 28:715-24
Dryanovski, Dilyan I; Guzman, Jaime N; Xie, Zhong et al. (2013) Calcium entry and *-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons. J Neurosci 33:10154-64

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