The Blood and Tissue Core services will be provided by the Center for Advanced Laboratory Medicine (CALM) at Columbia University Medical Center (CUMC). CALM provides access to a wide range of clinical laboratory services for clinical research at CUMC. CALM is the interface between the Clinical Laboratories at New York-Presbyterian Hospital and researchers, pharmaceutical companies, device manufacturers, and diagnostics companies. CALM provides a wide variety of support services for clinical research projects, clinical trials, and projects for the analytical and clinical assessment of new technology, equipment, testing methodologies, and testing protocols. CALM has provided an increasing array of services for the research projects of the Stroke Service, as detailed below. These include acute stroke trials, such as the Neuroprotection with Statin Therapy for Acute Recovery Trial (NeuSTART) within SPOTRIAS;epidemiological projects based at CUMC, such as the Northern Manhattan study and its ancillary studies;and multicenter stroke studies for which CALM sen/es as a laboratory core. Through its involvement in these projects, CALM has grown to become an essential part of the stroke research mission at CUMC. The Director of CALM, Steven L. Spitalnik, M.D., is board certified in Anatomic and Clinical Pathology with training in all aspects of laboratory medicine. Dr. Spitalnik is also the Vice-Chairman of the Division of Laboratory Medicine in the Department of Pathology and Cell Biology at CUMC. He has particular expertise in laboratory instrumentation, microbiology, transfusion medicine, clinical chemistry, molecular biology, and glycobiology. Consultation with other medical directors in the Division of Laboratory Medicine provides additional expertise in all areas of clinical pathology. In particular, the recent addition of Dr. Alex Rai to the faculty in the Division of Laboratory Medicine at CUMC, and as the Scientific Director of CALM, greatly enhances our capabilities in proteomics and personalized medicine. Dr. Spitalnik, other faculty members in Laboratory Medicine, and the technical staff of CALM are all available to assist in designing studies and preparing the laboratory testing components of IRB requests and grant applications.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center (P50)
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Special Emphasis Panel (ZNS1-SRB-R)
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Columbia University (N.Y.)
New York
United States
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Willey, Joshua Z; Khatri, Pooja; Khoury, Jane C et al. (2013) Variability in the use of intravenous thrombolysis for mild stroke: experience across the SPOTRIAS network. J Stroke Cerebrovasc Dis 22:318-22
Boden-Albala, Bernadette; Quarles, Leigh W (2013) Education strategies for stroke prevention. Stroke 44:S48-51
Willey, Joshua Z; Stillman, Joshua; Rivolta, Juan A et al. (2012) Too good to treat? Outcomes in patients not receiving thrombolysis due to mild deficits or rapidly improving symptoms. Int J Stroke 7:202-6
Katan, Mira; Elkind, Mitchell S V (2011) Inflammatory and neuroendocrine biomarkers of prognosis after ischemic stroke. Expert Rev Neurother 11:225-39
Zarahn, Eric; Alon, Leeor; Ryan, Sophia L et al. (2011) Prediction of motor recovery using initial impairment and fMRI 48 h poststroke. Cereb Cortex 21:2712-21
Marchidann, Adrian; Marshall, Randolph S (2011) Treatment of carotid artery disease: endarterectomy or angioplasty? Curr Neurol Neurosci Rep 11:61-6
Willey, Joshua Z; Elkind, Mitchell S V (2011) Stroke: do statins improve outcomes after acute ischemic stroke? Nat Rev Neurol 7:364-5
Dhamoon, Mandip S; Moon, Yeseon Park; Paik, Myunghee C et al. (2011) The inclusion of stroke in risk stratification for primary prevention of vascular events: the Northern Manhattan Study. Stroke 42:2878-82
Boden-Albala, Bernadette; Carman, Heather; Moran, Megan et al. (2011) Perception of recurrent stroke risk among black, white and Hispanic ischemic stroke and transient ischemic attack survivors: the SWIFT study. Neuroepidemiology 37:83-7
Lazar, Ronald M; Minzer, Brandon; Antoniello, Daniel et al. (2010) Improvement in aphasia scores after stroke is well predicted by initial severity. Stroke 41:1485-8

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