Abstract

This is an application for supplemental funding of Specialized Programs of Translational Research in Acute Stroke (SPOTRIAS) grant P50 NS055977,""""""""Washington University SPOTRIAS Center."""""""" We request support to develop web-based resources which promote SPOTRIAS research and education aims, (a) by development of the Stroke Trials Registry, an on-line database of randomized clinical trials in cerebrovascular disease, and (b) by development of a SPOTRIAS web site for internet and intranet access. Support of these on-line initiatives will allow us to better fulfill SPOTRIAS aims by reaching a wider audience in a cost efficient manner using up-to-date electronic methodology. This function will be administered as part of the SPOTRIAS Core which currently supports training and career development in clinical stroke research, and will be guided by regular interaction with SPOTRIAS investigators and trainees.

Public Health Relevance

This project will provide information about stroke research through open-access web sites. The Stroke Trials Registry provides valuable descriptions about ongoing and completed clinical trials in stroke and cerebrovascular disease. The SPOTRIAS web site will assist stroke researchers by collaboration and data sharing.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
3P50NS055977-03S1A1
Application #
7765201
Study Section
Special Emphasis Panel (ZNS1-SRB-G (37))
Program Officer
Janis, Scott
Project Start
2006-07-01
Project End
2013-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
3
Fiscal Year
2010
Total Cost
$217,577
Indirect Cost

  Institution

Name
Washington University
Department
Neurology
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Goyal, Manu S; Hoff, Brian G; Williams, Jennifer et al. (2016) Streamlined Hyperacute Magnetic Resonance Imaging Protocol Identifies Tissue-Type Plasminogen Activator-Eligible Stroke Patients When Clinical Impression Is Stroke Mimic. Stroke 47:1012-7
An, Hongyu; Ford, Andria L; Eldeniz, Cihat et al. (2016) Reperfusion Beyond 6 Hours Reduces Infarct Probability in Moderately Ischemic Brain Tissue. Stroke 47:99-105
Chen, Yasheng; Dhar, Rajat; Heitsch, Laura et al. (2016) Automated quantification of cerebral edema following hemispheric infarction: Application of a machine-learning algorithm to evaluate CSF shifts on serial head CTs. Neuroimage Clin 12:673-680
Diringer, Michael N; Dhar, Rajat; Scalfani, Michael et al. (2016) Effect of High-Dose Simvastatin on Cerebral Blood Flow and Static Autoregulation in Subarachnoid Hemorrhage. Neurocrit Care 25:56-63
An, Hongyu; Ford, Andria L; Chen, Yasheng et al. (2015) Defining the ischemic penumbra using magnetic resonance oxygen metabolic index. Stroke 46:982-8
Dhar, Rajat; Diringer, Michael N (2015) Relationship between angiographic vasospasm, cerebral blood flow, and cerebral infarction after subarachnoid hemorrhage. Acta Neurochir Suppl 120:161-5
Curfman, David; Connor, Lisa Tabor; Moy, Hawnwan Philip et al. (2014) Accuracy of emergency medical services-reported last known normal times in patients suspected with acute stroke. Stroke 45:1275-9
Rubin, Michael A; Dhar, Rajat; Diringer, Michael N (2014) Racial differences in withdrawal of mechanical ventilation do not alter mortality in neurologically injured patients. J Crit Care 29:49-53
Sanelli, P C; Sykes, J B; Ford, A L et al. (2014) Imaging and treatment of patients with acute stroke: an evidence-based review. AJNR Am J Neuroradiol 35:1045-51
Vellimana, Ananth K; Yarbrough, Chester K; Blackburn, Spiros et al. (2014) Intravenous tissue-type plasminogen activator therapy is an independent risk factor for symptomatic intracerebral hemorrhage after carotid endarterectomy. Neurosurgery 74:254-61

Showing the most recent 10 out of 44 publications