The goal of the Data Management and Biostatistics Core is to provide statistical and study design support to achieve the overall goal of PANUC;Understanding basic mechanisms that underiie cognitive impairment in PD. To achieve this goal, the Data Management and Biostatistics Core has the following four specific aims:
Aim 1. Enhance research productivity by serving a coordinating role for database development, data cleaning and organization for individual projects.
Aim 2. Facilitate conduct of PANUC projects by providing statistical and methodological support, data analysis and interpretation of results.
Aim 3. Foster collaborative research by facilitating data sharing across PANUC projects.
Aim 4. Facilitate dissemination of study results by assisting in manuscript development and preparation, and in organizing and preparing data for submission to national repositories and databases as required by NIH.

Public Health Relevance

(See Instructions): It is imperative that data management is well organized and that appropriate statistical methods are applied to ensure valid and meaningful results. The Data Management and Biostatistics Core (Core D) will provide this expertise to the Pacific Northwest Udall Center (PANUC), and will play a crucial role in discovering and investigating the mechanisms that underiie cognitive impairment in PD.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
5P50NS062684-05
Application #
8535847
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
5
Fiscal Year
2013
Total Cost
$209,886
Indirect Cost
$48,748
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
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Shi, Min; Liu, Changqin; Cook, Travis J et al. (2014) Plasma exosomal ?-synuclein is likely CNS-derived and increased in Parkinson's disease. Acta Neuropathol 128:639-50
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Gallardo, Christian M; Darvas, Martin; Oviatt, Mia et al. (2014) Dopamine receptor 1 neurons in the dorsal striatum regulate food anticipatory circadian activity rhythms in mice. Elife 3:e03781
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Cohen, Rajal G; Klein, Krystal A; Nomura, Mariko et al. (2014) Inhibition, executive function, and freezing of gait. J Parkinsons Dis 4:111-22
Nuytemans, Karen; Inchausti, Vanessa; Beecham, Gary W et al. (2014) Absence of C9ORF72 expanded or intermediate repeats in autopsy-confirmed Parkinson's disease. Mov Disord 29:827-30
Stewart, Tessandra; Sui, Yu-Ting; Gonzalez-Cuyar, Luis F et al. (2014) Cheek cell-derived *-synuclein and DJ-1 do not differentiate Parkinson's disease from control. Neurobiol Aging 35:418-20

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