CLINICAL CORE: ABSTRACT The Pacific Northwest Udall Center (PANUC) Clinical Resource Core has recruited and characterized a cohort of more than 600 individuals with PD during the initial funding period. Data from the PANUC Clinical Resource Core, in collaboration with other Udall Centers and other academic medical centers, have helped confirm Apolipoprotein E (APOE) and glucocerebrosidase (GBA) as genes which are relevant to the pathogenesis of cognitive decline in Parkinson's Disease (PD). Understanding the mechanisms underlying these gene effects is the focus of this renewal application, utilizing both model systems (Projects 1 and 2) and human subjects (Projects 3 and 4). The Clinical Resource Core will provide well-characterized PD and control subjects of appropriate genotypes for Projects 3 and 4. In addition, select members of the existing cohort will be retained for additional longitudinal clinical and neuropsychological testing follow-up to support ongoing genetic and biomarker studies, with a refined battery of tests and a reduced frequency of visits designed to maximize efficiency. Gait and balance testing will be added to the test battery as an innovation that is thought to reflect higher order CNS function closely related to cognition. This innovation leverages the expertise of Dr. Horak, an investigator introduced to the PANUC by way of PANUC pilot award funding during the last funding period. As in the first cycle, Clinical Resource Core subjects will be followed at two sites: one at UW directed by Dr. Hu, and the other at OHSU directed by Dr. Quinn. Dr. Horak will oversee gait and balance testing at both sites.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
2P50NS062684-06
Application #
8881524
Study Section
Special Emphasis Panel (ZNS1-SRB-J (07))
Project Start
2008-07-01
Project End
2015-07-31
Budget Start
2014-09-30
Budget End
2015-07-31
Support Year
6
Fiscal Year
2014
Total Cost
$750,576
Indirect Cost
$151,666
Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Flanagan, Margaret E; Cholerton, Brenna; Latimer, Caitlin S et al. (2018) TDP-43 Neuropathologic Associations in the Nun Study and the Honolulu-Asia Aging Study. J Alzheimers Dis 66:1549-1558
Gray, Shelly L; Anderson, Melissa L; Hanlon, Joseph T et al. (2018) Exposure to Strong Anticholinergic Medications and Dementia-Related Neuropathology in a Community-Based Autopsy Cohort. J Alzheimers Dis 65:607-616
Moreno, Monica A; Or-Geva, Noga; Aftab, Blake T et al. (2018) Molecular signature of Epstein-Barr virus infection in MS brain lesions. Neurol Neuroimmunol Neuroinflamm 5:e466
Condello, Carlo; Lemmin, Thomas; Stöhr, Jan et al. (2018) Structural heterogeneity and intersubject variability of A? in familial and sporadic Alzheimer's disease. Proc Natl Acad Sci U S A 115:E782-E791
Locke, Timothy M; Soden, Marta E; Miller, Samara M et al. (2018) Dopamine D1 Receptor-Positive Neurons in the Lateral Nucleus of the Cerebellum Contribute to Cognitive Behavior. Biol Psychiatry 84:401-412
Cholerton, Brenna; Johnson, Catherine O; Fish, Brian et al. (2018) Sex differences in progression to mild cognitive impairment and dementia in Parkinson's disease. Parkinsonism Relat Disord 50:29-36
Blue, Elizabeth E; Bis, Joshua C; Dorschner, Michael O et al. (2018) Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project. Dement Geriatr Cogn Disord 45:1-17
Houser, Madelyn C; Chang, Jianjun; Factor, Stewart A et al. (2018) Stool Immune Profiles Evince Gastrointestinal Inflammation in Parkinson's Disease. Mov Disord 33:793-804
Irwin, David J; Grossman, Murray; Weintraub, Daniel et al. (2017) Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. Lancet Neurol 16:55-65
Lee, Adél; Särkkä, Aila; Madhyastha, Tara M et al. (2017) Characterizing cross-subject spatial interaction patterns in functional magnetic resonance imaging studies: A two-stage point-process model. Biom J 59:1352-1381

Showing the most recent 10 out of 178 publications