The primary objecfive of the Clinical Resource Core (CRC) is to provide comprehensive programs for recruitment, community outreach and educafion, core clinical assessments, and genotyping and biological sample storage for all projects of the Udall Center. The CRC will also serve a coordinafion role between projects and cores to assure that all subjects participating in the projects of our Udall Center will complete a minimal multidisciplinary dataset, including the following: clinical rafings (off-state UPDRS), a standardized neuropsychological testing battery (see Cognitive and Behavioral core), off-state FDG PET, off-state, routine anatomical MRI, DNA banking (see below), and brain donation and banking when applicable. Data collected through the CRC will be shared with other Udail Centers and PD invesfigators at other institutions through the PD-DOC registry (see Stafisfics and Data Management Core).
This core will serve a critical funcfion in the proposed Udall Center by coordinating all aspects of subject recruitment, clinical assessments, as well as providing support for several of the anticipated investigational procedures.
|Tripathi, Madhavi; Tang, Chris C; Feigin, Andrew et al. (2016) Automated Differential Diagnosis of Early Parkinsonism Using Metabolic Brain Networks: A Validation Study. J Nucl Med 57:60-6|
|Vo, An; Sako, Wataru; Fujita, Koji et al. (2016) Parkinson's disease-related network topographies characterized with resting state functional MRI. Hum Brain Mapp :|
|Jourdain, Vincent A; Tang, Chris C; Holtbernd, Florian et al. (2016) Flow-metabolism dissociation in the pathogenesis of levodopa-induced dyskinesia. JCI Insight 1:e86615|
|Davis, Marie Y; Johnson, Catherine O; Leverenz, James B et al. (2016) Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease. JAMA Neurol 73:1217-1224|
|Lerner, Renata P; Bimpisidis, Zisis; Agorastos, Stergiani et al. (2016) Dissociation of metabolic and hemodynamic levodopa responses in the 6-hydroxydopamine rat model. Neurobiol Dis 96:31-37|
|Leaver, Katherine; Poston, Kathleen L (2015) Do CSF Biomarkers Predict Progression to Cognitive Impairment in Parkinson's disease patients? A Systematic Review. Neuropsychol Rev 25:411-23|
|Spetsieris, Phoebe G; Ko, Ji Hyun; Tang, Chris C et al. (2015) Metabolic resting-state brain networks in health and disease. Proc Natl Acad Sci U S A 112:2563-8|
|Ma, Yilong; Johnston, Tom H; Peng, Shichun et al. (2015) Reproducibility of a Parkinsonism-related metabolic brain network in non-human primates: A descriptive pilot study with FDG PET. Mov Disord 30:1283-8|
|MÃ¼ller-Oehring, Eva M; Sullivan, Edith V; Pfefferbaum, Adolf et al. (2015) Task-rest modulation of basal ganglia connectivity in mild to moderate Parkinson's disease. Brain Imaging Behav 9:619-38|
|Ko, Ji Hyun; Lerner, Renata P; Eidelberg, David (2015) Effects of levodopa on regional cerebral metabolism and blood flow. Mov Disord 30:54-63|
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