The Clinical Resource Core will provide support for the Human Research Projects (Projects II &III) of the U-M Udall Center through recruitment, enrollment, and detailed clinical and imaging assessment of Parkinson disease (PD) patients (N=95), progressive supranuclear palsy (PSP) patients (N=15), and age and gender matched normal control (NC) subjects (N=15). The Clinical Resource Core will have a standardized method for data collection, entry, and verification, as developed in coordination with the Biostatistics and Data Management Core (Core C), which will be in compliance with HIPAA and IRB regulations. Data collected will be consistent with NINDS Common Data Elements (CDEs) to facilitate ultimate transfer of data to a NINDS Data Management Repository (DMR). The Clinical Resource Core will interact on a regular basis with all other human subject components of the Udall Center. The specific goals of the Clinical Resource Core are: 1. To recruit, enroll, and retain PD, PSP, and age &gender matched NC subjects for the Udall Center Human Research Projects in support of their scientific goals. 2. To comprehensively assess all subjects with well-established clinical, motor, and neuropsychological instruments. 3. To perform vesicular monoaminergic transporter type-2 (VMAT2) positron emission tomography (PET) using [11C]DTBZ and brain magnetic resonance (MR) imaging. 4. To interact and coordinate with Projects II and III and other Cores to assure prompt and accurate clinical assessment, data transfer, and data analysis.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Specialized Center (P50)
Project #
Application #
Study Section
Special Emphasis Panel (ZNS1-SRB-J (07))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Ann Arbor
United States
Zip Code
Marino, Simeone; Xu, Jiachen; Zhao, Yi et al. (2018) Controlled feature selection and compressive big data analytics: Applications to biomedical and health studies. PLoS One 13:e0202674
Albin, Roger L (2018) Tourette syndrome: a disorder of the social decision-making network. Brain 141:332-347
Rektor, Ivan; Bohnen, Nicolaas I; Korczyn, Amos D (2018) Subtype definition of vascular parkinsonism. Parkinsonism Relat Disord 52:107-108
Dinov, Ivo D; Palanimalai, Selvam; Khare, Ashwini et al. (2018) Randomization-Based Statistical Inference: A Resampling and Simulation Infrastructure. Teach Stat 40:64-73
Antoniou, Nasia; Vlachakis, Dimitrios; Memou, Anna et al. (2018) A motif within the armadillo repeat of Parkinson's-linked LRRK2 interacts with FADD to hijack the extrinsic death pathway. Sci Rep 8:3455
Bohnen, Nicolaas I; Muller, Martijn (2018) Reader response: Odor identification as a biomarker of preclinical AD in older adults at risk. Neurology 90:343
Sarter, Martin; Phillips, Kyra B (2018) The neuroscience of cognitive-motivational styles: Sign- and goal-trackers as animal models. Behav Neurosci 132:1-12
Kim, Kamin; Bohnen, Nicolaas I; Müller, Martijn L T M et al. (2018) Compensatory dopaminergic-cholinergic interactions in conflict processing: Evidence from patients with Parkinson's disease. Neuroimage :
Miller, Nathaniel S; Chou, Kelvin L; Bohnen, Nicolaas I et al. (2018) Dopaminergic polymorphisms associated with medication responsiveness of gait in Parkinson's disease. Parkinsonism Relat Disord 48:54-60
Kalinin, Alexandr A; Allyn-Feuer, Ari; Ade, Alex et al. (2018) 3D Shape Modeling for Cell Nuclear Morphological Analysis and Classification. Sci Rep 8:13658

Showing the most recent 10 out of 100 publications