The Clinical Resource Core will provide support for the Human Research Projects (Projects II &III) of the U-M Udall Center through recruitment, enrollment, and detailed clinical and imaging assessment of Parkinson disease (PD) patients (N=95), progressive supranuclear palsy (PSP) patients (N=15), and age and gender matched normal control (NC) subjects (N=15). The Clinical Resource Core will have a standardized method for data collection, entry, and verification, as developed in coordination with the Biostatistics and Data Management Core (Core C), which will be in compliance with HIPAA and IRB regulations. Data collected will be consistent with NINDS Common Data Elements (CDEs) to facilitate ultimate transfer of data to a NINDS Data Management Repository (DMR). The Clinical Resource Core will interact on a regular basis with all other human subject components of the Udall Center. The specific goals of the Clinical Resource Core are: 1. To recruit, enroll, and retain PD, PSP, and age &gender matched NC subjects for the Udall Center Human Research Projects in support of their scientific goals. 2. To comprehensively assess all subjects with well-established clinical, motor, and neuropsychological instruments. 3. To perform vesicular monoaminergic transporter type-2 (VMAT2) positron emission tomography (PET) using [11C]DTBZ and brain magnetic resonance (MR) imaging. 4. To interact and coordinate with Projects II and III and other Cores to assure prompt and accurate clinical assessment, data transfer, and data analysis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Specialized Center (P50)
Project #
1P50NS091856-01
Application #
8882617
Study Section
Special Emphasis Panel (ZNS1-SRB-J (07))
Project Start
Project End
Budget Start
2014-09-30
Budget End
2015-06-30
Support Year
1
Fiscal Year
2014
Total Cost
$573,035
Indirect Cost
$204,524
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Bohnen, Nicolaas I; Haugen, Jacob; Ridder, Andrew et al. (2017) Color discrimination errors associate with axial motor impairments in Parkinson's disease. Mov Disord Clin Pract 4:864-869
Kotagal, Vikas; Bohnen, Nicolaas I; Müller, Martijn L T M et al. (2017) Cerebral Amyloid Burden and Hoehn and Yahr Stage 3 Scoring in Parkinson Disease. J Parkinsons Dis 7:143-147
Albin, Roger L; Leventhal, Daniel K (2017) The missing, the short, and the long: Levodopa responses and dopamine actions. Ann Neurol 82:4-19
Ridder, A; Müller, M L T M; Kotagal, V et al. (2017) Impaired contrast sensitivity is associated with more severe cognitive impairment in Parkinson disease. Parkinsonism Relat Disord 34:15-19
Miller, Nathaniel S; Chou, Kelvin L; Bohnen, Nicolaas I et al. (2017) Dopaminergic polymorphisms associated with medication responsiveness of gait in Parkinson's disease. Parkinsonism Relat Disord :
Rektor, Ivan; Bohnen, Nicolaas I; Korczyn, Amos D et al. (2017) An updated diagnostic approach to subtype definition of vascular parkinsonism - Recommendations from an expert working group. Parkinsonism Relat Disord :
Albin, Roger L (2017) Polyglutamine inclusion body toxicity. Mov Disord 32:1686
Gwinn, Katrina; David, Karen K; Swanson-Fischer, Christine et al. (2017) Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program. Biomark Med 11:451-473
Koshy Cherian, Ajeesh; Kucinski, Aaron; Pitchers, Kyle et al. (2017) Unresponsive Choline Transporter as a Trait Neuromarker and a Causal Mediator of Bottom-Up Attentional Biases. J Neurosci 37:2947-2959
Albin, Roger L (2017) Many genes involved in Tourette syndrome pathogenesis. Mov Disord 32:993

Showing the most recent 10 out of 68 publications