This grant requests 5 years of funding support for continuing operation of the Washington National Primate Research Center at the University of Washington (WaNPRC). The goal of this proposal is to support a broad-based research resources program, providing biomedical scientists the opportunity to conduct research using nonhuman primate (NHP) models for human health-related and NHP biologic issues. This goal will be attained through support for scientific intellectual resources, administration, animal support resources, facilities, and operations. Support is requested for translational and pre-clinical resource support in AIDS-related research, Neuroscience, NHP Systems Biology, Developmental and Reproductive Biology, and Global Programs (Research Cores). New research initiatives will develop novel NHP models and expand related research resources, including additional core scientists. Support for research resource related studies is requested to provide innovative research directions and better characterization of the NHP model. The WaNPRC will focus on efficient access to Center resources, with particular emphasis placed on support for affiliate research activities. This proposal also includes support for a broad program of animal care and technical support for breeding, housing, and research activities (Primate Resources Division), including both domestic and international sites of operation. Administrative support is requested to ensure appropriate management of Center finances and operations, focusing on improved efficiency and effective support for research activities. Support is requested for WaNPRC breeding colonies located in Seattle, WA and at our locations in New Iberia, LA and Alice, TX. All primates in WaNPRC facilities are housed and cared for under conditions that meet or exceed NIH standards per the Guide for the Care and Use of Laboratory Animals, ILAR recommendations, and the AAALAC accreditation standards for NHPs. All lentivirus-infected primates are housed in ABSL2/3 containment facilities with appropriate biosafety procedures. The University of Washington, including the WaNPRC, is fully accredited by AAALAC International.
; The Washington National Primate Research Center provides the necessary non-human primate disease models for a variety of diseases and conditions that affect humans such as HIV/AIDS, influenza, Parkinson's disease, and neonatal asphyxia. The availability of these models allows for the development of preventive and interventive medicine and medical techniques to improve public health.
|Berger, Carolina; Sommermeyer, Daniel; Hudecek, Michael et al. (2015) Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells. Cancer Immunol Res 3:206-16|
|Worlein, Julie M (2014) Nonhuman primate models of depression: effects of early experience and stress. ILAR J 55:259-73|
|Novak, Melinda A; Hamel, Amanda F; Coleman, Kris et al. (2014) Hair loss and hypothalamic-pituitary-adrenocortical axis activity in captive rhesus macaques (Macaca mulatta). J Am Assoc Lab Anim Sci 53:261-6|
|Peng, Xinxia; Alföldi, Jessica; Gori, Kevin et al. (2014) The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease. Nat Biotechnol 32:1250-5|
|Zhou, Tian; Hu, Minlu; Pearlman, Andrew et al. (2014) Expression and localization of p-glycoprotein, multidrug resistance protein 4, and breast cancer resistance protein in the female lower genital tract of human and pigtailed macaque. AIDS Res Hum Retroviruses 30:1106-16|
|Duan, Jinghua; Freeling, Jennifer P; Koehn, Josefin et al. (2014) Evaluation of atazanavir and darunavir interactions with lipids for developing pH-responsive anti-HIV drug combination nanoparticles. J Pharm Sci 103:2520-9|
|Falzarano, Darryl; de Wit, Emmie; Feldmann, Friederike et al. (2014) Infection with MERS-CoV causes lethal pneumonia in the common marmoset. PLoS Pathog 10:e1004250|
|Puller, Christian; Manookin, Michael B; Neitz, Maureen et al. (2014) Specialized synaptic pathway for chromatic signals beneath S-cone photoreceptors is common to human, Old and New World primates. J Opt Soc Am A Opt Image Sci Vis 31:A189-94|
|Neitz, Maureen; Neitz, Jay (2014) Curing color blindness--mice and nonhuman primates. Cold Spring Harb Perspect Med 4:a017418|
|Hariri, Sepideh; Johnstone, Murray; Jiang, Yi et al. (2014) Platform to investigate aqueous outflow system structure and pressure-dependent motion using high-resolution spectral domain optical coherence tomography. J Biomed Opt 19:106013|
Showing the most recent 10 out of 29 publications