This grant requests 5 years of funding support for continuing operation of the Washington National Primate Research Center at the University of Washington (WaNPRC). The goal of this proposal is to support a broad-based research resources program, providing biomedical scientists the opportunity to conduct research using nonhuman primate (NHP) models for human health-related and NHP biologic issues. This goal will be attained through support for scientific intellectual resources, administration, animal support resources, facilities, and operations. Support is requested for translational and pre-clinical resource support in AIDS-related research, Neuroscience, NHP Systems Biology, Developmental and Reproductive Biology, and Global Programs (Research Cores). New research initiatives will develop novel NHP models and expand related research resources, including additional core scientists. Support for research resource related studies is requested to provide innovative research directions and better characterization of the NHP model. The WaNPRC will focus on efficient access to Center resources, with particular emphasis placed on support for affiliate research activities. This proposal also includes support for a broad program of animal care and technical support for breeding, housing, and research activities (Primate Resources Division), including both domestic and international sites of operation. Administrative support is requested to ensure appropriate management of Center finances and operations, focusing on improved efficiency and effective support for research activities. Support is requested for WaNPRC breeding colonies located in Seattle, WA and at our locations in New Iberia, LA and Alice, TX. All primates in WaNPRC facilities are housed and cared for under conditions that meet or exceed NIH standards per the Guide for the Care and Use of Laboratory Animals, ILAR recommendations, and the AAALAC accreditation standards for NHPs. All lentivirus-infected primates are housed in ABSL2/3 containment facilities with appropriate biosafety procedures. The University of Washington, including the WaNPRC, is fully accredited by AAALAC International.
; The Washington National Primate Research Center provides the necessary non-human primate disease models for a variety of diseases and conditions that affect humans such as HIV/AIDS, influenza, Parkinson's disease, and neonatal asphyxia. The availability of these models allows for the development of preventive and interventive medicine and medical techniques to improve public health.
|Adams Waldorf, Kristina M; Stencel-Baerenwald, Jennifer E; Kapur, Raj P et al. (2016) Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate. Nat Med 22:1256-1259|
|Forero, Adriana; Tisoncik-Go, Jennifer; Watanabe, Tokiko et al. (2016) The 1918 Influenza Virus PB2 Protein Enhances Virulence through the Disruption of Inflammatory and Wnt-Mediated Signaling in Mice. J Virol 90:2240-53|
|Townsley, Samantha; Mohamed, Zeinab; Guo, Wenjin et al. (2016) Induction of Heterologous Tier 2 HIV-1-Neutralizing and Cross-Reactive V1/V2-Specific Antibodies in Rabbits by Prime-Boost Immunization. J Virol 90:8644-60|
|Manuzak, Jennifer A; Hensley-McBain, Tiffany; Zevin, Alexander S et al. (2016) Enhancement of Microbiota in Healthy Macaques Results in Beneficial Modulation of Mucosal and Systemic Immune Function. J Immunol 196:2401-9|
|Hofsteen, Peter; Robitaille, Aaron M; Chapman, Daniel Patrick et al. (2016) Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/Î²-catenin signaling. Proc Natl Acad Sci U S A 113:1002-7|
|Meister, Miriam L R; Buffalo, Elizabeth A (2016) Getting directions from the hippocampus: The neural connection between looking and memory. Neurobiol Learn Mem 134 Pt A:135-44|
|Kiorpes, Lynne (2016) The Puzzle of Visual Development: Behavior and Neural Limits. J Neurosci 36:11384-11393|
|Curtis, Britni; Liberato, Noelle; Rulien, Megan et al. (2016) Erratum: "Examination of the Safety of Pediatric Vaccine Schedules in a Non-Human Primate Model: Assessments of Neurodevelopment, Learning, and Social Behavior". Environ Health Perspect 124:A11|
|Tisoncik-Go, Jennifer; Gasper, David J; Kyle, Jennifer E et al. (2016) Integrated Omics Analysis of Pathogenic Host Responses during Pandemic H1N1 Influenza Virus Infection: The Crucial Role of Lipid Metabolism. Cell Host Microbe 19:254-66|
|El-Shamayleh, Yasmine; Pasupathy, Anitha (2016) Contour Curvature As an Invariant Code for Objects in Visual Area V4. J Neurosci 36:5532-43|
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