Abstract

The WaNPRC Pilot Program provides support for innovative and potentially high risk, high impact preliminary studies using nonhuman primates. The program goals include developing new nonhuman primate models for biomedical research, acquiring preliminary data for subsequent grant application, or successive human clinical studies. This program is significant in that funding for preliminary, explorative investigation is extremely difficult to secure. The Pilot Program offers PIs an opportunity to obtain limited support for preliminary studies focused on development of new models or ?proof of concept?. These studies can potentially provide significant impact through development of new NHP models or providing essential preliminary data for subsequent grant submission. In some cases, these studies can provide necessary information to inform decisions for ensuing human clinical studies. The WaNPRC Pilot program is conducted collaboratively with the Institute for Translational Health Sciences at the University of Washington.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Primate Research Center Grants (P51)
Project #
2P51OD010425-56
Application #
9207551
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2017-05-01
Budget End
2018-04-30
Support Year
56
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Veterinary Sciences
Type
Primate Centers
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Adams Waldorf, Kristina M; Nelson, Branden R; Stencel-Baerenwald, Jennifer E et al. (2018) Congenital Zika virus infection as a silent pathology with loss of neurogenic output in the fetal brain. Nat Med 24:368-374
Mitchell, Timothy; MacDonald, James W; Srinouanpranchanh, Sengkeo et al. (2018) Evidence of cardiac involvement in the fetal inflammatory response syndrome: disruption of gene networks programming cardiac development in nonhuman primates. Am J Obstet Gynecol 218:438.e1-438.e16
Choi, Hannah; Pasupathy, Anitha; Shea-Brown, Eric (2018) Predictive Coding in Area V4: Dynamic Shape Discrimination under Partial Occlusion. Neural Comput 30:1209-1257
Cole, Amy L; Cosgrove Sweeney, Yvonne; Lasseter, Amanda G et al. (2018) Evaluation of the Pig-Tailed Macaque (Macaca nemestrina) as a Model of Human Staphylococcus aureus Nasal Carriage. Infect Immun 86:
Kraft, John C; Treuting, Piper M; Ho, Rodney J Y (2018) Indocyanine green nanoparticles undergo selective lymphatic uptake, distribution and retention and enable detailed mapping of lymph vessels, nodes and abnormalities. J Drug Target 26:494-504
Gulinello, Maria; Mitchell, Heather A; Chang, Qiang et al. (2018) Rigor and reproducibility in rodent behavioral research. Neurobiol Learn Mem :
Kraft, John C; McConnachie, Lisa A; Koehn, Josefin et al. (2018) Mechanism-based pharmacokinetic (MBPK) models describe the complex plasma kinetics of three antiretrovirals delivered by a long-acting anti-HIV drug combination nanoparticle formulation. J Control Release 275:229-241
Wool, Lauren E; Crook, Joanna D; Troy, John B et al. (2018) Nonselective Wiring Accounts for Red-Green Opponency in Midget Ganglion Cells of the Primate Retina. J Neurosci 38:1520-1540
Jing, Jing; Petroff, Rebekah; Shum, Sara et al. (2018) Toxicokinetics and Physiologically Based Pharmacokinetic Modeling of the Shellfish Toxin Domoic Acid in Nonhuman Primates. Drug Metab Dispos 46:155-165
Pallus, Adam C; Walton, Mark M G; Mustari, Michael J (2018) Activity of near response cells during disconjugate saccades in strabismic monkeys. J Neurophysiol :

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