This application requests funding for the Tulane National Primate Research Center (TNPRC) for the five year period beginning May 1, 2013 through April 30, 2018. Funds will be used to support the administration, operations, veterinary resources, scientific research resources, pilot research program, improvements and modernization, outreach, and education and training activities of the Center. For nearly three decades, the main focus of the TNPRC research program has been infectious diseases. In addition, a program in regenerative medicine has developed, which Is closely linked to the Center for Stem Cell Research and Regenerative Medicine at Tulane. The major agent-specific areas of funding for the infectious diseases program are currently AIDS, Lyme disease, tuberculosis and biodefense-related agents. These are multidisciplinary studies involving investigators in several Divisions at the TNPRC and collaborators outside the Center. Common to these studies is a focus on disease pathogenesis and on using such findings to inform the development of vaccines, diagnostics and therapeutics. The regenerative medicine program allows novel approaches to the treatment of many types of disease, provides diversity to our research program, and provides an important link to the rest of the university. The period since the last submission of the TNPRC base grant, at the end of May 2007, has been a time of significant growth and change at the Center. Individual investigator-Initiated award funding has doubled and three new buildings have been completed, one of which is a Regional Biosafety Laboratory;a large biosafety level 3 facility. The TNPRC is the only NPRC to have a Regional Biosafety Laboratory. We have also expanded our South Campus to allow future growth of the nonhuman primate breeding colony. Based on the progress in the funding period, we are optimistic about the future. Strengths on which we can capitalize Include unique resources and capabilities In research areas that match NIH and national priorities, faculty appointments, strong and diverse research resources, a talented and dedicated staff, excellent interactions and collaborations with area universities and an outstanding relationship with our host institution and state and federal legislators.

Public Health Relevance

The TNPRC has a mission to Improve human and animal health through basic and applied biomedical research. We focus on health Issues that require the use of nonhuman primates (NHPs) and serve as a national resource for biomedical research using NHPs. Hundreds of investigators/year rely on the resources of the TNPRC to conduct NIH-funded research.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Primate Research Center Grants (P51)
Project #
3P51OD011104-53S4
Application #
8903483
Study Section
Special Emphasis Panel (ZRR1-CM-6 (01))
Program Officer
Harding, John D
Project Start
1997-05-09
Project End
2018-04-30
Budget Start
2014-08-15
Budget End
2015-04-30
Support Year
53
Fiscal Year
2014
Total Cost
$319,823
Indirect Cost
$25,285
Name
Tulane University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
053785812
City
New Orleans
State
LA
Country
United States
Zip Code
70118
Alvarez, Xavier; Midkiff, Cecily; Kuroda, Marcelo J et al. (2014) Detecting the simian immunodeficiency virus reservoir as viral DNA and RNA in situ simultaneously as a model to monitor viral latency. AIDS Res Hum Retroviruses 30:205-6
Mohan, Mahesh; Chandra, Lawrance C; Torben, Workineh et al. (2014) miR-190b is markedly upregulated in the intestine in response to simian immunodeficiency virus replication and partly regulates myotubularin-related protein-6 expression. J Immunol 193:1301-13
Ling, Binhua; Piatak Jr, Michael; Rogers, Linda et al. (2014) Effects of treatment with suppressive combination antiretroviral drug therapy and the histone deacetylase inhibitor suberoylanilide hydroxamic acid; (SAHA) on SIV-infected Chinese rhesus macaques. PLoS One 9:e102795
Monjure, C J; Tatum, C D; Panganiban, A T et al. (2014) Optimization of PCR for quantification of simian immunodeficiency virus genomic RNA in plasma of rhesus macaques (Macaca mulatta) using armored RNA. J Med Primatol 43:31-43
Snook, Eric R; Fisher-Perkins, Jeanne M; Sansing, Hope A et al. (2014) Innate immune activation in the pathogenesis of a murine model of globoid cell leukodystrophy. Am J Pathol 184:382-96
Roy, Chad J; Adams, A Paige; Wang, Eryu et al. (2014) Chikungunya vaccine candidate is highly attenuated and protects nonhuman primates against telemetrically monitored disease following a single dose. J Infect Dis 209:1891-9
Lee, Kim M; Chiu, Kevin B; Renner, Nicole A et al. (2014) Form follows function: astrocyte morphology and immune dysfunction in SIV neuroAIDS. J Neurovirol 20:474-84
Gautam, Uma S; Mehra, Smriti; Ahsan, Muhammad H et al. (2014) Role of TNF in the altered interaction of dormant Mycobacterium tuberculosis with host macrophages. PLoS One 9:e95220
McGillivray, Amanda; Golden, Nadia Abrahams; Gautam, Uma Shankar et al. (2014) The Mycobacterium tuberculosis Rv2745c plays an important role in responding to redox stress. PLoS One 9:e93604
Loganantharaj, Nisha; Nichols, Whitney A; Bagby, Gregory J et al. (2014) The effects of chronic binge alcohol on the genital microenvironment of simian immunodeficiency virus-infected female rhesus macaques. AIDS Res Hum Retroviruses 30:783-91

Showing the most recent 10 out of 40 publications