This application seeks five years of continued support for the Base Grant (P51 RR00165) for the Yerkes National Primate Research Center of Emory University. The operation ofthe Yerkes NPRC is guided by the NCRR Program Guidelines for NPRCs (Sixth Edition). The YNPRC, as documented herein, has recorded substantial progress in the present reporting period, and also here presents comprehensive plans for the next five years (5/1/2011 - 4/30/2016). The objectives in this application are aligned to our mission of providing the comprehensive research infrastructure required to conduct a research program largely funded by extramural grants and other funding mechanisms, chiefly from NIH. Continued P51 funding is requested for all or part ofthe following components to support the Center's scientific mission: Administration, including scientific leadership and overall management, business services, information technology, human resources, and public affairs;Facilities Management;Research Resources, including veterinary medicine, animal care, colony management, animal records, and behavioral management;as vi/ell as service pathology, environmental health and safety, and research services to provide comprehensive support to outside investigators;and three Science Service Cores: Biomarkers, Imaging, and Virology. Support is also sought for four scientific divisions: Microbiology and Immunology, Neuropharmacology and Neurologic Diseases, Developmental and Cognitive Neuroscience and Behavioral Neuroscience and Psychiatric Disorders. Additionally, support is requested for five Pilot Research Projects to allow Center investigators to collect preliminary data and develop improved methodologies in areas likely to lead to subsequent external support. Support is also sought for two resource enhancement grants. Finally, support is requested under Improvement and Modernization to enhance elements ofthe infrastructure. The Yerkes NPRCs central goal is to support a research program focused on scientific problems relevant to human health, and to provide the resource infrastructure and expertise in appropriate scientific and veterinary specialties to support such a program. Additional Yerkes goals are to enhance the Center's ability to serve as a resource to core investigators and to scientists nationally and internationally, as well as to provide educational and training opportunities.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Primate Research Center Grants (P51)
Project #
3P51OD011132-53S1
Application #
8829365
Study Section
Special Emphasis Panel ()
Program Officer
Harding, John D
Project Start
1997-05-01
Project End
2016-04-30
Budget Start
2014-04-11
Budget End
2014-04-30
Support Year
53
Fiscal Year
2014
Total Cost
$63,770
Indirect Cost
$19,791
Name
Emory University
Department
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Paspalas, Constantinos D; Carlyle, Becky C; Leslie, Shannon et al. (2018) The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology. Alzheimers Dement 14:680-691
Mavigner, Maud; Habib, Jakob; Deleage, Claire et al. (2018) Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques. J Virol 92:
Dobolyi, Arpad; Cservenák, Melinda; Young, Larry J (2018) Thalamic integration of social stimuli regulating parental behavior and the oxytocin system. Front Neuroendocrinol 51:102-115
Fisher, Bridget S; Green, Richard R; Brown, Rachel R et al. (2018) Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART. PLoS Pathog 14:e1006871
Snyder, Brooke R; Chan, Anthony W S (2018) Progress in developing transgenic monkey model for Huntington's disease. J Neural Transm (Vienna) 125:401-417
Wetzel, Katherine S; Yi, Yanjie; Yadav, Anjana et al. (2018) Loss of CXCR6 coreceptor usage characterizes pathogenic lentiviruses. PLoS Pathog 14:e1007003
Stammen, Rachelle L; Cohen, Joyce K; Meeker, Tracy L et al. (2018) Effect of Chronic Social Stress on Prenatal Transfer of Antitetanus Immunity in Captive Breeding Rhesus Macaques (Macaca mulatta). J Am Assoc Lab Anim Sci 57:357-367
Mars, Rogier B; Sotiropoulos, Stamatios N; Passingham, Richard E et al. (2018) Whole brain comparative anatomy using connectivity blueprints. Elife 7:
Hickman, Heather D; Suthar, Mehul S (2018) Editorial overview: Viral immunology: Generating immunity to diverse viral pathogens. Curr Opin Virol 28:viii-x
Pitts, Elizabeth G; Li, Dan C; Gourley, Shannon L (2018) Bidirectional coordination of actions and habits by TrkB in mice. Sci Rep 8:4495

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