The objective of this proposal is to continue support of the infrastructure of the Southwest National Primate Research Center (SNPRC). The SNPRC is located on the campus of the Southwest Foundation for Biomedical Research, its host institution. The SNPRC maintains over 4,000 nonhuman primates, primarily baboons, macaques, marmosets, and chimpanzees. It maintains large breeding populations of baboons, rhesus macaques, and common marmosets. During the current grant period, the SNPRC provided resources to 290 investigators from 35 states. The base grant is composed of four types of components: Administration, Primate Resources, Veterinary Resources, and Research Resources. The Research Resource components and the research programs that utilize them are divided among four Focus Groups: Infectious Diseases and Biodefense, Chronic Diseases, Development and Aging, and Genomics. The mission of the SNPRC is "To improve the health of our global community through innovative biomedical research with nonhuman primates." Consistent with this mission, the SNPRC is committed to translational research and is a partner in two CTSA applications that are in review. The administration, primate resource, veterinary resource, and research resource infrastructures supported by the base grant enable the SNPRC to be responsive to national biomedical research needs and to accommodate investigators who want to access Center resources for collaborative research purposes. Special, and in some cases unique, strengths of the SNPRC are a wide variety of primate species to meet diverse research needs;the largest pedigreed and genotyped population of nonhuman primates available for genetic research;broad research opportunities with the largest chimpanzee population at any National Primate Research Center;ABSL-3 and ABSL-4 facilities;research emphasis and expertise on gene discovery for common chronic diseases, development of vaccines and drugs for infectious diseases, preventions and treatments of neonatal diseases, and stem cell biology;and service as a national resource for genetic management of nonhuman primates.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Primate Research Center Grants (P51)
Project #
3P51OD011133-15S1
Application #
8705077
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Program Officer
Harding, John D
Project Start
1999-06-06
Project End
2014-04-30
Budget Start
2013-09-01
Budget End
2014-04-30
Support Year
15
Fiscal Year
2013
Total Cost
$399,007
Indirect Cost
$175,849
Name
Texas Biomedical Research Institute
Department
Type
DUNS #
007936834
City
San Antonio
State
TX
Country
United States
Zip Code
78245
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Manickam, Cordelia; Rajakumar, Premeela; Wachtman, Lynn et al. (2016) Acute Liver Damage Associated with Innate Immune Activation in a Small Nonhuman Primate Model of Hepacivirus Infection. J Virol 90:9153-62
Schlabritz-Loutsevitch, Natalia; Gygax, Scott E; Dick Jr, Edward et al. (2016) Vaginal Dysbiosis from an Evolutionary Perspective. Sci Rep 6:26817
Jensen, Jeffrey T; Hanna, Carol; Yao, Shan et al. (2016) Transcervical administration of polidocanol foam prevents pregnancy in female baboons. Contraception 94:527-533
Lutz, Corrine K; Coleman, Kris; Worlein, Julie M et al. (2016) Factors influencing alopecia and hair cortisol in rhesus macaques (Macaca mulatta). J Med Primatol 45:180-8

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