The objective of this proposal is to continue support of the infrastructure of the Southwest National Primate Research Center (SNPRC). The SNPRC is located on the campus of the Texas Biomedical Research Institute, its host institution. The SNPRC maintains approximately 2,500 nonhuman primates, primarily baboons, macaques, marmosets, and chimpanzees. It maintains breeding populations of baboons, rhesus macaques, and common marmosets. The base grant is composed of Administration components;SNPRC Service components which includes the various veterinary, research, and behavioral service units of the SNPRC;Animal Colony components for the baboons, macaques, marmosets, and chimpanzees;the Immunology Core Laboratory;and two Resource Related Research Projects, one on Genomics and one on Metabolic Disease Profiling. The research programs in the Center are based in one of three Research Facilitation Groups. These groups provide expertise and support to investigators conducting research in the Center. The groups are Infectious Disease and Biodefense;Metabolic Diseases and Genomics;and Physiology, Behavior and Basic Medicine. The mission of the SNPRC is to improve the health of our global community through innovative biomedical research with nonhuman primates. Consistent with this mission, the SNPRC is committed to translational research. The administration, primate resources, veterinary resources, and research resource infrastructures supported by the base grant enable the SNPRC to be responsive to national biomedical research needs and to accommodate investigators who want to access Center resources for collaborative research purposes. Special, and in some cases unique, strengths of the SNPRC are a wide variety of primate species to meet diverse research needs;the largest pedigreed and genotyped population of nonhuman primates available for genetic research;research opportunities with chimpanzees;ABSL-3 and ABSL-4 facilities;and research emphasis and expertise on gene discovery for common chronic diseases, development of vaccines, drugs for infectious disease, and stem cell biology.

Public Health Relevance

The Southwest National Primate Research Center (SNPRC) facilitates innovative biomedical research that advances human health through provision of nonhuman primate-related resources to investigators from around the country. The SNPRC maintains colonies of baboons, macaques, marmosets, and chimpanzees for support of biomedical research projects. The Center also has internal research efforts focused on genomics, metabolic disease, infectious disease, and behavior.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Primate Research Center Grants (P51)
Project #
Application #
Study Section
Special Emphasis Panel (ZOD1-CM-6 (03))
Program Officer
Harding, John D
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Texas Biomedical Research Institute
San Antonio
United States
Zip Code
Novak, Melinda A; Hamel, Amanda F; Coleman, Kris et al. (2014) Hair loss and hypothalamic-pituitary-adrenocortical axis activity in captive rhesus macaques (Macaca mulatta). J Am Assoc Lab Anim Sci 53:261-6
Marmoset Genome Sequencing and Analysis Consortium (2014) The common marmoset genome provides insight into primate biology and evolution. Nat Genet 46:850-7
Higgins, Paul B; Rodriguez, Perla J; Voruganti, V Saroja et al. (2014) Body composition and cardiometabolic disease risk factors in captive baboons (Papio hamadryas sp.): sexual dimorphism. Am J Phys Anthropol 153:9-14
Tackney, Justin; Cawthon, Richard M; Coxworth, James E et al. (2014) Blood cell telomere lengths and shortening rates of chimpanzee and human females. Am J Hum Biol 26:452-60
Parker Jr, C R; Grizzle, W E; Blevins, J K et al. (2014) Development of adrenal cortical zonation and expression of key elements of adrenal androgen production in the chimpanzee (Pan troglodytes) from birth to adulthood. Mol Cell Endocrinol 387:35-43
Dick Jr, Edward J; Owston, Michael A; David, John M et al. (2014) Mortality in captive baboons (Papio spp.): a-23-year study. J Med Primatol 43:169-96
Lutz, Corrine K; Williams, Priscilla C; Sharp, R Mark (2014) Abnormal behavior and associated risk factors in captive baboons (Papio hamadryas spp.). Am J Primatol 76:355-61
Bailey, Adam L; Lauck, Michael; Sibley, Samuel D et al. (2014) Two novel simian arteriviruses in captive and wild baboons (Papio spp.). J Virol 88:13231-9
Szabó, C Akos; Knape, Koyle D; Leland, M Michelle et al. (2014) Craniofacial trauma as a clinical marker of seizures in a baboon colony. Comp Med 64:135-9
Hinojosa-Laborde, Carmen; Shade, Robert E; Muniz, Gary W et al. (2014) Validation of lower body negative pressure as an experimental model of hemorrhage. J Appl Physiol (1985) 116:406-15

Showing the most recent 10 out of 34 publications