The objective of this proposal is to continue support of the infrastructure of the Southwest National Primate Research Center (SNPRC). The SNPRC is located on the campus of the Texas Biomedical Research Institute, its host institution. The SNPRC maintains approximately 2,500 nonhuman primates, primarily baboons, macaques, marmosets, and chimpanzees. It maintains breeding populations of baboons, rhesus macaques, and common marmosets. The base grant is composed of Administration components;SNPRC Service components which includes the various veterinary, research, and behavioral service units of the SNPRC;Animal Colony components for the baboons, macaques, marmosets, and chimpanzees;the Immunology Core Laboratory;and two Resource Related Research Projects, one on Genomics and one on Metabolic Disease Profiling. The research programs in the Center are based in one of three Research Facilitation Groups. These groups provide expertise and support to investigators conducting research in the Center. The groups are Infectious Disease and Biodefense;Metabolic Diseases and Genomics;and Physiology, Behavior and Basic Medicine. The mission of the SNPRC is to improve the health of our global community through innovative biomedical research with nonhuman primates. Consistent with this mission, the SNPRC is committed to translational research. The administration, primate resources, veterinary resources, and research resource infrastructures supported by the base grant enable the SNPRC to be responsive to national biomedical research needs and to accommodate investigators who want to access Center resources for collaborative research purposes. Special, and in some cases unique, strengths of the SNPRC are a wide variety of primate species to meet diverse research needs;the largest pedigreed and genotyped population of nonhuman primates available for genetic research;research opportunities with chimpanzees;ABSL-3 and ABSL-4 facilities;and research emphasis and expertise on gene discovery for common chronic diseases, development of vaccines, drugs for infectious disease, and stem cell biology.

Public Health Relevance

The Southwest National Primate Research Center (SNPRC) facilitates innovative biomedical research that advances human health through provision of nonhuman primate-related resources to investigators from around the country. The SNPRC maintains colonies of baboons, macaques, marmosets, and chimpanzees for support of biomedical research projects. The Center also has internal research efforts focused on genomics, metabolic disease, infectious disease, and behavior.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Primate Research Center Grants (P51)
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Special Emphasis Panel (ZOD1-CM-6 (03))
Program Officer
Harding, John D
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Texas Biomedical Research Institute
San Antonio
United States
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Coleman, Kristine; Lutz, Corrine K; Worlein, Julie M et al. (2017) The correlation between alopecia and temperament in rhesus macaques (Macaca mulatta) at four primate facilities. Am J Primatol 79:1-10
Laurence, Hannah; Kumar, Shyamesh; Owston, Michael A et al. (2017) Natural mortality and cause of death analysis of the captive chimpanzee (Pan troglodytes): A 35-year review. J Med Primatol 46:106-115
Kumar, Shyamesh; Laurence, Hannah; Owston, Michael A et al. (2017) Natural pathology of the captive chimpanzee (Pan troglodytes): A 35-year review. J Med Primatol 46:271-290
Salinas, Felipe S; Szabó, Charles Ákos (2017) Resting-state functional connectivity changes due to acute and short-term valproic acid administration in the baboon model of GGE. Neuroimage Clin 16:132-141
Morosco, Danielle T; Cline, Curtis R; Owston, Michael A et al. (2017) Spontaneous mediastinal myeloid sarcoma in a common marmoset (Callithrix jacchus) and review of the veterinary literature. J Med Primatol 46:42-47
Malloy, Kristen E; Li, Jinqi; Choudhury, Gourav R et al. (2017) Magnetic Resonance Imaging-Guided Delivery of Neural Stem Cells into the Basal Ganglia of Nonhuman Primates Reveals a Pulsatile Mode of Cell Dispersion. Stem Cells Transl Med 6:877-885
Kuo, A H; Li, J; Li, C et al. (2017) Prenatal steroid administration leads to adult pericardial and hepatic steatosis in male baboons. Int J Obes (Lond) 41:1299-1302
Proffitt, J Michael; Glenn, Jeremy; Cesnik, Anthony J et al. (2017) Proteomics in non-human primates: utilizing RNA-Seq data to improve protein identification by mass spectrometry in vervet monkeys. BMC Genomics 18:877
Höglind, Ankie; Areström, Irene; Ehrnfelt, Cecilia et al. (2017) Systematic evaluation of monoclonal antibodies and immunoassays for the detection of Interferon-? and Interleukin-2 in old and new world non-human primates. J Immunol Methods 441:39-48
Bordt, Andrea S; Long, Ye; Kouyama, Nobuo et al. (2017) Wavy multistratified amacrine cells in the monkey retina contain immunoreactive secretoneurin. Peptides 94:33-42

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