This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Influenza A viruses continue to be a public health concern due to the mortality and morbidity associated with seasonal influenza and pandemic influenza. Moreover, the 2009 H1N1 outbreak serves as a reminder of the ability of influenza viruses to generate strains that can cause global pandemics, and that influenza viruses continue to pose a significant threat to public health. Of all the pandemics caused by the influenza viruses in the 20th century, the 1918 pandemic, or """"""""Spanish influenza"""""""", was by far the most devastating. One of the intriguing outcomes of the 1918 pandemic is the fact that mortality was highest in young adults and not aged individuals. Two hypotheses can explain this outcome: 1) the dampened adaptive immune response in elderly individuals protected them against destruction by the immune system;2) the presence of cross-neutralizing antibodies directed against other H1N1 viruses protected older individuals. The only way to test these hypotheses is to utilize an animal model where the presence of cross-neutralizing antibodies can be controlled. In these studies we propose to: 1. Define the contribution of viral and host genes to the global host response to infection. 2. Characterize age-related differences in disease progression and host immune response.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000163-52
Application #
8357863
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2011-05-01
Project End
2012-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
52
Fiscal Year
2011
Total Cost
$58,239
Indirect Cost
Name
Oregon Health and Science University
Department
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Meyer, Thomas J; Held, Ulrike; Nevonen, Kimberly A et al. (2016) The Flow of the Gibbon LAVA Element Is Facilitated by the LINE-1 Retrotransposition Machinery. Genome Biol Evol 8:3209-3225
Chadderdon, S M; Belcik, J T; Bader, L et al. (2016) Vasoconstrictor eicosanoids and impaired microvascular function in inactive and insulin-resistant primates. Int J Obes (Lond) 40:1600-1603
Dufour, Brett D; McBride, Jodi L (2016) Intravascular AAV9 Administration for Delivering RNA Silencing Constructs to the CNS and Periphery. Methods Mol Biol 1364:261-75
Slayden, Ov Daniel (2016) Translational In Vivo Models for Women's Health: The Nonhuman Primate Endometrium--A Predictive Model for Assessing Steroid Receptor Modulators. Handb Exp Pharmacol 232:191-202
Pleil, Kristen E; Helms, Christa M; Sobus, Jon R et al. (2016) Effects of chronic alcohol consumption on neuronal function in the non-human primate BNST. Addict Biol 21:1151-1167
Barr, Tasha; Girke, Thomas; Sureshchandra, Suhas et al. (2016) Alcohol Consumption Modulates Host Defense in Rhesus Macaques by Altering Gene Expression in Circulating Leukocytes. J Immunol 196:182-95
Xu, Jing; McGee, Whitney K; Bishop, Cecily V et al. (2015) Exposure of female macaques to Western-style diet with or without chronic T in vivo alters secondary follicle function during encapsulated 3-dimensional culture. Endocrinology 156:1133-42
Sullivan, Elinor L; Riper, Kellie M; Lockard, Rachel et al. (2015) Maternal high-fat diet programming of the neuroendocrine system and behavior. Horm Behav 76:153-61
Jensen, Jeffrey T; Hanna, Carol; Yao, Shan et al. (2015) Characterization of tubal occlusion after transcervical polidocanol foam (PF) infusion in baboons. Contraception 92:96-102
Halliley, Jessica L; Tipton, Christopher M; Liesveld, Jane et al. (2015) Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow. Immunity 43:132-45

Showing the most recent 10 out of 426 publications