This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Syndecans are mammalian cell surface proteins that are believed to be involved in HIV infection of cells. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. One of these, syndecan 1 is a heparin sulfate molecule that antibodies have been made against in an attempt to utilize this approach for microbicide development. Our collaborators from Scripps Res Institute have found that blocking syndecans on the surface of cells with specific anti-syndecan antibody fragments (Fab syndecan antagonists) prevents attachment and transport of HIV through mucosal cell monolayers and can prevent HIV infection and growth in cells in vitro. Since syndecan receptors on the cell surface are also involved in attachment and transport of other sexually transmitted diseases (i.e., herpes and gonorrhea) this approach has an advantage over HIV specific microbicides, as it may prevent several sexually transmitted diseases in addition to HIV. However, in preliminary testing, these agonists or antagonists neither protected macaques against vaginal SHIV Transmission.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000164-50
Application #
8358179
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2011-05-01
Project End
2012-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
50
Fiscal Year
2011
Total Cost
$57,750
Indirect Cost
Name
Tulane University
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
053785812
City
New Orleans
State
LA
Country
United States
Zip Code
70118
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