This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goal of this project is to define the effects of different structural forms of the aggregated protein A? on the brain. In Alzheimer's disease, A? (a protein normally generated by brain cells) becomes misfolded and binds to other A? molecules, forming senile plaques and cerebral amyloid angiopathy. Our lab has shown that the aggregation of A? can be stimulated by exposure to brain extracts from patients with Alzheimer's disease. This past year we have begun studies to isolate the seed itself, to assess its ability to induce aggregation, and to determine whether there are different structural/functional subtypes of A?.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
2P51RR000165-51
Application #
8357481
Study Section
Special Emphasis Panel (ZRR1-CM-5 (01))
Project Start
2011-08-01
Project End
2012-04-30
Budget Start
2011-08-01
Budget End
2012-04-30
Support Year
51
Fiscal Year
2011
Total Cost
$20,580
Indirect Cost
Name
Emory University
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
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