To assess the effect of advancing age upon the development of lumbar spine degenerative arthritis in rhesus monkeys and the use of a custom central region of interest to minimize the impact of this process upon the bone mineral density as measured by DXA. RESULTS The prevalence of degenerative spinal arthritis dramatically increases at age 19 in female rhesus monkeys. Utilization of our custom central region of interest analysis program allows demonstration of ovariectomy induced bone loss with comparable sensitivity as standard analysis and does demonstrate an age-related decline in lumbar spine bone mineral density. FUTURE DIRECTIONS Application of similar custom region of interest analysis programs to human clinical DXA scans to assess if this improves the diagnostic sensitivity by excluding the spurious elevation of BMD due to degenerative spinal arthritis. KEY WORDS Osteoporosis, age-related, bone density FUNDING Geriatrics section discretionary funds PUBLICATIONS Krueger, D., Todd, H., Haffa, A., Bruner, J., Yandow, D., & Binkley, N. Use of central region of interest analysis in AP spine DXA. (Presented at ISCD annual meeting, 1/98). [A] Krueger, D., Vallarta-Ast, N., & Binkley N. Lumbar Spine Densitometry Vertebral Region of Interest Analysis in Older Adults Bone, 23(5 suppl) S485. [A]

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000167-41
Application #
6454362
Study Section
Project Start
2001-05-01
Project End
2002-04-30
Budget Start
Budget End
Support Year
41
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
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