To determine whether periaqueductal gray (PAG) neurons that project to the nucleus retroambiguus (NRA) are immunoreactive for estrogen receptor-alpha. In three ovariectomized female monkeys, injections with cholera toxin subunit b (CTb) were made into the NRA to retrogradely label neurons in the periaqueductal gray (PAG). Using immunohistochemistry, estrogen receptors (ER)-alpha containing neurons were identified in the same tissue. The results indicate that the PAG contains large numbers of neurons that project to the NRA and numerous ER-alpha immunoreactive neurons. Although the distribution pattern partly overlaps, only a small number of neurons were double labeled for CTb and ER-alpha. These neurons were mainly present in the ventrolateral PAG. FUTURE DIRECTIONS The data needs to be plotted and quantified. KEY WORDS nucleus retroambiguus, periaqueuductal gray, estrogen receptor-alpha. FUNDING Supplemental funding to RR00167

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000167-41
Application #
6454297
Study Section
Project Start
2001-05-01
Project End
2002-04-30
Budget Start
Budget End
Support Year
41
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
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