This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.To evaluate feeding and metabolism in rhesus monkeys in response to chemical or electrical stimulation of the hypothalamus. Morbid obesity is a major health problem that is suboptimally treated at present. Current procedures to control appetite and obesity suffer from either low efficacy or high morbidity and mortality. The hypothalamus plays a critical role in regulating appetite and energy balance. More specifically, the lateral hypothalamus appears to regulate hunger while the ventral medial hypothalamus (VMH) regulates satiety. The exact loci and pathways through which this is accomplished remain unclear. During the current report period we successfully completed a pilot project as planned and the project is finished. The data from this project provide a foundation for future studies of feeding and metabolism. This research used WNPRC Animal Services and Centralized Protocol Implementation services.
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