This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.Enveloped viruses have multiple mechanisms by which they inhibit infection of a target cell by more than one virion. Here we investigate the ability of influenza A virus hemagglutinin (HA), neuraminidase (NA), and M2 protein pumps to block entry of HA-pseudotyped retroviruses and infectious H1N1 and H3N2 influenza A viruses. We observed that NA from multiple isolates, but not HA or M2 or an enzymatically inactive form of NA, inhibited viral superinfection.
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