This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The proposed project will longitudinally address two important questions: (1) How do maternal condition and life history tradeoffs affect lactational investment and subsequent reproduction, (2) How do differences in lactational investment program infant developmental trajectories? Studies of maternal investment strategies in primates have focused mainly on the behavior of lactating females and their infants, documenting the frequency of suckling, proximity maintenance, and the dynamics of weaning. To date we know little about factors that influence the primary form of maternal investment, milk synthesis. Previous research in rhesus macaques has demonstrated that milk synthesis is influenced by maternal life history, reproductive experience, and infant sex. Additionally this research suggests that the milk energy available soon after birth is a nutritional cue that calibrates the infant's behavior and temperament to environmental and maternal conditions, and that this calibration has consequences for reproductive fitness. The proposed study will augment and extend these findings in the large captive population of rhesus macaques at the California National Primate Research Center. Longitudinal comparisons of lactation performance within and among mothers and the consequences for infant growth and behavioral development will indicate how mothers manipulate lactational investment in relation to their own, and their infant's, physiological and social condition. This research project will provide the first systematic longitudinal information investigating all dimensions of mammalian lactation strategies within a single species (milk synthesis, nursing behavior, duration of lactation until weaning, and number and sex-ratio of infants supported during lactation). As such this study will explore fundamental aspects of lactation that have previously not been investigated, and advance our understanding of how selection has shaped maternal investment strategies. The data from this study will directly address critical issues affecting the health of mothers and their infants. Breastfeeding rates in the US and throughout the world are significantly below optimum, contributing to long-term deleterious developmental and health consequences for infants. Advances in understanding how constraints during lactation influence the nutritional value of the mother's milk, under controlled research conditions will provide insight into similar challenges for human mothers and provide vital information for current global health concerns. This research will provide valuable resources, in the form of archived samples and public databases, for other researchers studying evolutionary theory (sex-biased investment strategies) to mechanistic explanations (the role of milk cortisol influencing infant metabolic programming).

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR000169-50
Application #
8357328
Study Section
Special Emphasis Panel (ZRR1-CM-5 (01))
Project Start
2011-05-01
Project End
2012-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
50
Fiscal Year
2011
Total Cost
$50,419
Indirect Cost
Name
University of California Davis
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
047120084
City
Davis
State
CA
Country
United States
Zip Code
95618
Day, George Q; Ng, Jillian; Oldt, Robert F et al. (2018) DNA-based Determination of Ancestry in Cynomolgus Macaques (Macaca fascicularis). J Am Assoc Lab Anim Sci 57:432-442
Carroll, Timothy D; Jegaskanda, Sinthujan; Matzinger, Shannon R et al. (2018) A Lipid/DNA Adjuvant-Inactivated Influenza Virus Vaccine Protects Rhesus Macaques From Uncontrolled Virus Replication After Heterosubtypic Influenza A Virus Challenge. J Infect Dis 218:856-867
Midic, Uros; VandeVoort, Catherine A; Latham, Keith E (2018) Determination of single embryo sex in Macaca mulatta and Mus musculus RNA-Seq transcriptome profiles. Physiol Genomics 50:628-635
Almodovar, Sharilyn; Swanson, Jessica; Giavedoni, Luis D et al. (2018) Lung Vascular Remodeling, Cardiac Hypertrophy, and Inflammatory Cytokines in SHIVnef-Infected Macaques. Viral Immunol 31:206-222
Ciupe, Stanca M; Miller, Christopher J; Forde, Jonathan E (2018) A Bistable Switch in Virus Dynamics Can Explain the Differences in Disease Outcome Following SIV Infections in Rhesus Macaques. Front Microbiol 9:1216
Comrie, Alison E; Gray, Daniel T; Smith, Anne C et al. (2018) Different macaque models of cognitive aging exhibit task-dependent behavioral disparities. Behav Brain Res 344:110-119
Feng, Jun-Feng; Liu, Jing; Zhang, Lei et al. (2017) Electrical Guidance of Human Stem Cells in the Rat Brain. Stem Cell Reports 9:177-189
Han, Pengcheng; Nielsen, Megan; Song, Melissa et al. (2017) The Impact of Aging on Brain Pituitary Adenylate Cyclase Activating Polypeptide, Pathology and Cognition in Mice and Rhesus Macaques. Front Aging Neurosci 9:180
Pittet, Florent; Johnson, Crystal; Hinde, Katie (2017) Age at reproductive debut: Developmental predictors and consequences for lactation, infant mass, and subsequent reproduction in rhesus macaques (Macaca mulatta). Am J Phys Anthropol 164:457-476
Kyle, Colin T; Stokes, Jared; Bennett, Jeffrey et al. (2017) Cytoarchitectonically-driven MRI atlas of nonhuman primate hippocampus: Preservation of subfield volumes in aging. Hippocampus :

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