This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff.
This research aims to further our understanding of the neurobiological mechanisms underlying social support in the context of friendship. Countless studies have identified social support as critical in protecting individuals from the deleterious mental and physical health consequences of both acute and chronic stressors (Uchino et al., 1996), yet the underlying neurobiological mechanisms remain unclear. The importance of examining the specific mechanisms underlying friendship is underlined by the fact that friends are vital for the healthy psychosocial adjustment of children (Erath et al., 2010), and an understanding of the mechanisms by which friends act as social buffers to immature individuals may explain why more socially isolated youngsters are at greater risk for developing mental and physical illnesses later in life (Bagwell et al., 1998). This project has three specific goals: 1) To identify brain areas involved in juvenile rhesus monkey (Macaca mulatta) friendships using non-invasive imaging techniques (i.e. positron emission tomography);2) To determine the effectiveness of a friend versus a familiar companion in reducing brain activity in regions known to mediate stress and anxiety;3) To examine the associations between behavior, brain activity, and central and peripheral levels of oxytocin, vasopressin, and cortisol within the context of friendship. We hypothesize that 1) the neural circuitry of friendship shares in common many of the pathways that have been implicated in attachment relationships;2) the presence of a friend during exposure to a psychosocial stressor, as compared with the presence of a familiar peer, will be associated with reduced activity in limbic structures typically involved in responding to threatening experiences, which will in turn reduce cortisol levels;and 3) the presence of a friend during exposure to a psychosocial stressor, as compared with the presence of a familiar peer, will be associated with increased affiliation, which will activate central oxytocin- and vasopressin-releasing neurons and result in higher levels of these neuropeptides in cerebrospinal fluid and plasma.

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Primate Research Center Grants (P51)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CM-5 (01))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Davis
Veterinary Sciences
Schools of Veterinary Medicine
United States
Zip Code
Han, Pengcheng; Nielsen, Megan; Song, Melissa et al. (2017) The Impact of Aging on Brain Pituitary Adenylate Cyclase Activating Polypeptide, Pathology and Cognition in Mice and Rhesus Macaques. Front Aging Neurosci 9:180
Pittet, Florent; Johnson, Crystal; Hinde, Katie (2017) Age at reproductive debut: Developmental predictors and consequences for lactation, infant mass, and subsequent reproduction in rhesus macaques (Macaca mulatta). Am J Phys Anthropol 164:457-476
Zhang, Xinjun; Kanthaswamy, Sree; Trask, Jessica S et al. (2017) Genetic Characterization of a Captive Colony of Pigtailed Macaques (Macaca nemestrina). J Am Assoc Lab Anim Sci 56:390-395
Jensen, Kara; Dela Pena-Ponce, Myra Grace; Piatak Jr, Michael et al. (2017) Balancing Trained Immunity with Persistent Immune Activation and the Risk of Simian Immunodeficiency Virus Infection in Infant Macaques Vaccinated with Attenuated Mycobacterium tuberculosis or Mycobacterium bovis BCG Vaccine. Clin Vaccine Immunol 24:
Rose, Destanie R; Careaga, Milo; Van de Water, Judy et al. (2017) Long-term altered immune responses following fetal priming in a non-human primate model of maternal immune activation. Brain Behav Immun 63:60-70
Hasan, M Kamrul; Feeroz, M Mostafa; Jones-Engel, Lisa et al. (2016) Performing monkeys of Bangladesh: characterizing their source and genetic variation. Primates 57:221-30
Austin, Christine; Smith, Tanya M; Farahani, Ramin M Z et al. (2016) Uncovering system-specific stress signatures in primate teeth with multimodal imaging. Sci Rep 6:18802
Scott, Julia A; Grayson, David; Fletcher, Evan et al. (2016) Longitudinal analysis of the developing rhesus monkey brain using magnetic resonance imaging: birth to adulthood. Brain Struct Funct 221:2847-71
Rueda, Cesar M; Presicce, Pietro; Jackson, Courtney M et al. (2016) Lipopolysaccharide-Induced Chorioamnionitis Promotes IL-1-Dependent Inflammatory FOXP3+ CD4+ T Cells in the Fetal Rhesus Macaque. J Immunol 196:3706-15
Bliss-Moreau, Eliza; Moadab, Gilda (2016) Variation in Behavioral Reactivity Is Associated with Cooperative Restraint Training Efficiency. J Am Assoc Lab Anim Sci 55:41-9

Showing the most recent 10 out of 393 publications