This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Data Management and Computing Core (CORE UNIT B) 1) will provide database management services to the projects which will be generating and analyzing phenotypic, genotypic, and gene expression data within the Program Project and 2) will also provide high-throughput analytical computational support to the research efforts proposed. Core B will ensure data quality control, support applications oftware, provide network and systems management for computers used in this Program Project, and protect the security of project data.
Specific aims of this core during the proposed grant period are 1) to assist, facilitate, and validate -- based on pedigree relationships -- the selection of specific animals for the proposed research projects;2) to manage acquisition, entry, and control of computerized data used in this Program Project;3) to manage inter-laboratory file transfer;4) to process laboratory data and maintain the software used for processing;5) to control the quality of the data collected;6) to transform raw data into forms suitable for genetic analysis;7) to protect the security/integrity of collected data;8) to further develop and enhance software used in this Program Project as needed;9) to undertake systems programming tasks as needed to maintain the computer system and its communications network;10) to provide backup for data and systems files;11) to protect the security of the computers used in this Program Project;and 12) to provide state-of-the-art computational support for the high-throughput analyses required in the four associated scientific projects. The four proposed research projects supported by this Core Unit represent the natural extension of more than two decades of research with the pedigreed baboon model. In addition to the management and processing of the data collected during the proposed funding period, Core B is also an important source of continuity between past efforts to establish, manage, and characterize the large baboon pedigrees, and detect and localize genes responsible for variation in atherosclerosis risk factors. The proposed efforts of Core B will contribute to identification and analysis of function of genes with data obtained from baboons from these same extended pedigrees.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR013986-13
Application #
8357663
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2011-05-01
Project End
2012-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
13
Fiscal Year
2011
Total Cost
$77,235
Indirect Cost
Name
Texas Biomedical Research Institute
Department
Type
DUNS #
007936834
City
San Antonio
State
TX
Country
United States
Zip Code
78245
Kumar, Shyamesh; Laurence, Hannah; Owston, Michael A et al. (2017) Natural pathology of the captive chimpanzee (Pan troglodytes): A 35-year review. J Med Primatol 46:271-290
Morosco, Danielle T; Cline, Curtis R; Owston, Michael A et al. (2017) Spontaneous mediastinal myeloid sarcoma in a common marmoset (Callithrix jacchus) and review of the veterinary literature. J Med Primatol 46:42-47
Muralimanoharan, Sribalasubashini; Li, Cun; Nakayasu, Ernesto S et al. (2017) Sexual dimorphism in the fetal cardiac response to maternal nutrient restriction. J Mol Cell Cardiol 108:181-193
Rodriguez-Sanchez, Iram P; Guindon, Josee; Ruiz, Marco et al. (2016) The endocannabinoid system in the baboon (Papio spp.) as a complex framework for developmental pharmacology. Neurotoxicol Teratol 58:23-30
Neidig, Lauren E; Owston, Michael A; Ball, Erin et al. (2016) Pauci-immune glomerulonephritis in a captive chimpanzee (Pan troglodytes), and a review of spontaneous cases in animals. J Med Primatol 45:336-341
Gharpure, Poorva; Kontogiorgos, Elias D; Opperman, Lynne A et al. (2016) Elastic Properties of Chimpanzee Craniofacial Cortical Bone. Anat Rec (Hoboken) 299:1718-1733
Schlabritz-Loutsevitch, Natalia; Gygax, Scott E; Dick Jr, Edward et al. (2016) Vaginal Dysbiosis from an Evolutionary Perspective. Sci Rep 6:26817
Ákos Szabó, C; Salinas, Felipe S; Li, Karl et al. (2016) Modeling the effective connectivity of the visual network in healthy and photosensitive, epileptic baboons. Brain Struct Funct 221:2023-33
Schlabritz-Loutsevitch, Natalia E; Comuzzie, Anthony G; Mahaney, Michael M et al. (2016) Serum Vitamin D Concentrations in Baboons (Papio spp.) during Pregnancy and Obesity. Comp Med 66:137-42
Bauer, Cassondra; Harrison, Tara (2016) Retrospective Analysis of the Incidence of Retained Placenta in 3 Large Colonies of NHP. Comp Med 66:143-9

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