This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The goals of this project are to generate tools and population resources for research on Chagas disease in human subjects and nonhuman primate models. Chagas disease affects 16-18 million people in Latin America, where it is the most prevalent cause of morbidity and mortality from heart disease. Chagas disease is an emerging disease in the US. Nonhuman primates housed in outdoor caging in southern US are naturally exposed to the insects that carry the disease-causing parasite and 2-10% of animals at the SNPRC are infected (percentage dependent on species). The grant provides bridge funding for an NIH grant on the genetics of Chagas disease in a human population in rural Brazil. It also funds the establishment of sensitive PCR diagnostic methods, the genetic characterization of the parasites endemic to Texas, the determination of feasibility of transporting infected blood from human subjects in Brazil to Texas for diagnostic work on the parasites, and assessment of disease progression by determining pathology in hearts from infected monkeys that die spontaneously or are euthanized for health reasons.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR013986-13
Application #
8357671
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2011-05-01
Project End
2012-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
13
Fiscal Year
2011
Total Cost
$27,074
Indirect Cost
Name
Texas Biomedical Research Institute
Department
Type
DUNS #
007936834
City
San Antonio
State
TX
Country
United States
Zip Code
78245
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Morosco, Danielle T; Cline, Curtis R; Owston, Michael A et al. (2017) Spontaneous mediastinal myeloid sarcoma in a common marmoset (Callithrix jacchus) and review of the veterinary literature. J Med Primatol 46:42-47
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Schlabritz-Loutsevitch, Natalia E; Comuzzie, Anthony G; Mahaney, Michael M et al. (2016) Serum Vitamin D Concentrations in Baboons (Papio spp.) during Pregnancy and Obesity. Comp Med 66:137-42
Bauer, Cassondra; Harrison, Tara (2016) Retrospective Analysis of the Incidence of Retained Placenta in 3 Large Colonies of NHP. Comp Med 66:143-9

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