This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. To date, no commercial vaccine is available to protect against infection with filoviruses. The overall aim of our project is to develop a safe and effective Ebola/Marburg vaccine based on MVA BN?-Filo vaccine to induce protective immunity to these highly pathogenic viral agents. Two weeks prior to vaccination, blood will be collected to establish an immunological baseline. On day -42 and -14 prior to challenge, animals will be either immunized with MVA BN-FILO vaccine or mock vaccinated. On day 0, all animals will be challenged with either Marburg or Ebola virus by intramuscular injection. At day -42, -14, 0, 4, 7, and 14, blood will be collected via femoral venipuncture for analysis for serology, hematology, chemistry and viral load determination. At day 21 post challenge, animals will be euthanized and tissue collected for viral load determination and histology.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Primate Research Center Grants (P51)
Project #
5P51RR013986-13
Application #
8357705
Study Section
Special Emphasis Panel (ZRR1-CM-8 (01))
Project Start
2011-05-01
Project End
2012-04-30
Budget Start
2011-05-01
Budget End
2012-04-30
Support Year
13
Fiscal Year
2011
Total Cost
$65,127
Indirect Cost
Name
Texas Biomedical Research Institute
Department
Type
DUNS #
007936834
City
San Antonio
State
TX
Country
United States
Zip Code
78245
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Morosco, Danielle T; Cline, Curtis R; Owston, Michael A et al. (2017) Spontaneous mediastinal myeloid sarcoma in a common marmoset (Callithrix jacchus) and review of the veterinary literature. J Med Primatol 46:42-47
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Schlabritz-Loutsevitch, Natalia E; Comuzzie, Anthony G; Mahaney, Michael M et al. (2016) Serum Vitamin D Concentrations in Baboons (Papio spp.) during Pregnancy and Obesity. Comp Med 66:137-42
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